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We are focused on understanding the pathways and molecular mechanisms that ensure accurate genome inheritance during cell division. Errors in genome inheritance are the cause of birth defects and are implicated in both cancer initiation and progression. In addition, the machinery involved in genome inheritance is a prominent target in cancer chemotherapy. Our interest in cell division stems from a long-standing fascination with the microtubule cytoskeleton, comprised of highly dynamic protein polymers that employ energy from assembly-coupled nucleotide hydrolysis to perform useful work in the cell. This interest led us to focus on the kinetochore, the macromolecular machine assembled on the centromere regions of chromosomes during cell division in order to harness the intrinsic dynamics of microtubule polymers for chromosome segregation.
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