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The emphasis of our studies is to develop and refine the technology necessary to isolate one of these rare stem cells, the mesenchymal stem cell (MSC). The MSC gives rise to bone-forming cells, cartilage-forming cells and cells of tendon, ligament fat, and dermis, as well as various connective tissues including the stroma of marrow. Following isolation and by mitotically expanding their numbers in culture, we can drive these cells down specific and different developmental pathways with emphasis on cartilage and bone. The experimental approaches use the classical information of both morphogenesis and organogenesis coupled with the new information of the control of developmental lineage progression as controlled by potent growth factors. The knowledge gained from animal models will be directly applied to the study of human MSC, as our preliminary studies have already proven to be successful. These studies integrate both basic scientists and clinicians to more effectively translate these basic science findings into new, innovative human health care protocols of using tissue engineering to repair skeletal tissues as in this accompanying figure.
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Tissue Engineering Part A (2024)
Elsevier eBookspp.105-125, (2024)
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npj Regenerative Medicineno. 1 (2024): 1-16
Christian Prusinski, Dan Yan,Johana Klasova, Kimberly H McVeigh,Sadia Z Shah,Olga P Fermo,Eva Kubrova,Ellen M Farr, Linus C Williams, Gerardo Gerardo-Manrique,Thomas F Bergquist, Si M Pham,
Cureusno. 5 (2024): e59478-e59478
PHARMACEUTICALSno. 2 (2023)
Journal of Cystic Fibrosis (2023): S19-S20
bioRxiv : the preprint server for biologyno. 6 (2023): S-209-S209
EXPERIMENTAL BIOLOGY AND MEDICINEno. 13 (2023): 1173-1180
Valery Adorno-Cruz, Golam Kibria,Xia Liu,Mary Doherty,Damian J. Junk, Dongyin Guan,Chris Hubert, Monica Venere,Erin Mulkearns-Hubert,Maksim Sinyuk,Alvaro Alvarado,Arnold I. Caplan,
crossref(2023)
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