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Bio
The long-term goals of my research are to develop a deeper understanding of the role of adenosine receptors in the control of bone homeostasis and to develop novel therapeutic agents for use in treatment of diseases of bone. Over the years, as both an undergraduate and graduate student, I have been involved in successful research into the physiology of the eye and was able to apply my skills understanding the role of purinergic receptors in ocular homeostasis. These studies also prepared me to carry out the type of translational and signaling studies I did in a postdoctoral stay in NYU School of Medicine. Since then I have developed an interest in bone physiology and pathology and I have been able to successfully apply the studies into potential translational targeting of purinergic receptors for bone resorption, new bone formation, inflammatory bone loss and myeloma. Although my primary research interest was focused in bone, I collaborated in other projects related to the role of purines in the regulation of physiologic and pharmacologic functions of inflammation, wound healing and fibrosis. During that time I had enough freedom to design my own experiments, and I helped to design and execute experiments supported by Pharma. Currently I’m involved in development of intellectual property on which I am listed as an inventor (Patents listed on the CV). Indeed, this freedom to design my own experiments and the experience in translational medicine I have, helps me to obtain my actual research position as a young scientist. Since 2016 I work in Hospital Fundación Jiménez Díaz under the program Miguel Servet and I am leading my own research focus on bone and muscle comorbidities under inflamatory situations (HIV infection, rheumatoid arthritis, frailty...) and how to counteract them targeting purinergic signaling. During these years I have published first- and last-authored papers in high quality journals, including Science Translational Medicine, Journal of Bone Mineral Research and Arthritis & Rheumatology (top rated journals in their field). My research has allowed me to became membrer of the following societies: SEIOMM (Sociedad Española de Investigación Ósea y Metabolismo Mineral), SER (Sociedad Española de Reumatología), ACR (American college of Rheumathology), SEBBM (Sociedad Española de Bioquímica y Biología Molecular), Purines and Pirymidines Society. I have to mention I have successfully supervised three doctoral thesis, one that was defended on November 2019, the second was defended on July 2022 and the third one is expected for June 2022. I have also been involved in supervising students under different educational grades, starting with high school students, undergraduate, graduate student, master student and medicine students. Moreover, I am reviewer for several journals: FASEB J, Inflammation, Journal of Pain Research, Mediators of inflammation, Drug Design Development and Therapy, Nutrients, Biochemical Pharmacology, Journal of Orthopedics & Rheumatology, Clinical Interventions in Aging, Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders, Journal of Physiology and Biochemistry, Archives of Biotechnology and Biomedicine among others. Moreover, since December 2019 I am a reviewer for research grants in 'Frontier Science 2019' CONACYT Mexico, and since Demeber 2021 I am also a reviewer for the Natural Sciences and Engineering Research Council of Canada (NSERC).
Research Interests
Papers共 146 篇Author StatisticsCo-AuthorSimilar Experts
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M. Marco-Bonilla, Marı́a José Fresnadillo, Isabel Monedero Sánchez, Raquel Largo,Gabriel Herrero‐Beaumont,Aránzazu Mediero
Annals of the Rheumatic Diseasesno. Suppl 1 (2023): 826.1-826
GELSno. 3 (2023): 176-176
Juan Pablo Medina, Ismael Bermejo-Álvarez,Sandra Pérez-Baos,Rosa Yáñez,María Fernández-García,Damián García-Olmo,Aránzazu Mediero, Gabriel Herrero-Beaumont, Raquel Largo
Frontiers in immunology (2023): 1193179-1345777
Ismael Bermejo-Álvarez,Sandra Pérez-Baos,Paula Gratal,Juan Pablo Medina, Raquel Largo, Gabriel Herrero-Beaumont,Aránzazu Mediero
Juan Pablo Medina, Ismael Bermejo-Alvarez,Sandra Perez-Baos,Rosa Yanez,Maria Fernandez-Garcia, Damian Garcia-Olmo,Aranzazu Mediero, Gabriel Herrero-Beaumont, Raquel Largo
FRONTIERS IN IMMUNOLOGY (2023)
Miguel Marco-Bonilla,Raquel Herencia,María Fresnadillo,Fernando Huete-Toral,Gonzalo Carracedo, Raquel Largo, Gabriel Herrero-Beaumont,Aránzazu Mediero
Frontiers in pharmacology (2023): 1247664-1247664
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 23 (2023): 16904
Paula Gratal,Aránzazu Mediero,Ana Lamuedra,Alejandra Matamoros‐Recio,Carmen Herencia, Gabriel Herrero‐Beaumont,Sonsoles Martín‐Santamaría, Raquel Largo
British Journal of Pharmacology (2022)
Ane Larrañaga-Vera,Kiran S. Toti, James S. Flatow, Alexandra J. Haraczy,Eugene Warnick,Harsha Rao,Zhan-Guo Gao,Sarah M. Sussman,Aranzazu Mediero,Philipp Leucht,Kenneth A. Jacobson,Bruce N. Cronstein
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