基本信息
views: 4
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
Research Interests
Human pluripotent stem cells (hPSCs) have enormous potential for use in regenerative medicine, in patient-specific screening and as a model for understanding human development. HPSCs encompass both human embryonic stem cells (hESCs) derived from the inner cell mass of the blastocyst, and human induced pluripotent stem cells (hiPSCs), which are derived from reprogramming somatic cells back to the pluripotent state. HiPSCs derived from patients with genetic diseases can be used as a human cellular model of the disease, thus enabling mechanistic studies and pre-clinical drug screening. However there are many critical hurdles that preclude the translation of hPSCs clinical potential into practice including poor survival and self-renewal upon dissociation, potential for genetic instability and tumorigenesis, and inefficient differentiation. Our laboratory interests have centered on identifying regulators of these three key processes in hPSCs. Elucidating the regulatory mechanisms controlling survival/self-renewal, stability and differentiation will improve our understanding of regulation of the pluripotent state and provide inroads into use of these cells in regenerative medicine. A main focus of the lab is interested in understanding the role of intrinsic and extrinsic signals involved in directing muscle differentiation from hPSCs as well as development of a novel reprogramming platform for muscle differentiation. This will improve our basic understanding of human muscle specification and could provide regenerative approaches for treatments of muscle disorders including muscular dystrophy.
Human pluripotent stem cells (hPSCs) have enormous potential for use in regenerative medicine, in patient-specific screening and as a model for understanding human development. HPSCs encompass both human embryonic stem cells (hESCs) derived from the inner cell mass of the blastocyst, and human induced pluripotent stem cells (hiPSCs), which are derived from reprogramming somatic cells back to the pluripotent state. HiPSCs derived from patients with genetic diseases can be used as a human cellular model of the disease, thus enabling mechanistic studies and pre-clinical drug screening. However there are many critical hurdles that preclude the translation of hPSCs clinical potential into practice including poor survival and self-renewal upon dissociation, potential for genetic instability and tumorigenesis, and inefficient differentiation. Our laboratory interests have centered on identifying regulators of these three key processes in hPSCs. Elucidating the regulatory mechanisms controlling survival/self-renewal, stability and differentiation will improve our understanding of regulation of the pluripotent state and provide inroads into use of these cells in regenerative medicine. A main focus of the lab is interested in understanding the role of intrinsic and extrinsic signals involved in directing muscle differentiation from hPSCs as well as development of a novel reprogramming platform for muscle differentiation. This will improve our basic understanding of human muscle specification and could provide regenerative approaches for treatments of muscle disorders including muscular dystrophy.
Research Interests
Papers共 82 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Michael R. Hicks,Kholoud K. Saleh,Ben Clock,Devin E. Gibbs, Mandee Yang,Shahab Younesi,Lily Gane, Victor Gutierrez-Garcia,Haibin Xi,April D. Pyle
Nature Cell Biologyno. 2 (2024): 306-306
Frontiers in physiology (2023): 1190524
Current opinion in genetics & development (2023): 102133-102133
William Dorst,Elizabeth Gibbs, Jonathan Nguyen,Jesus Perez, Laura Hagerty,Michael R. Emami,Niclas E. Bengtsson,Jeffrey S. Chamberlain,April D. Pyle,Melissa J. Spencer,Courtney S. Young
MOLECULAR THERAPYno. 4 (2023): 332-332
Cited0Views0Bibtex
0
0
Michael R Hicks,Kholoud K Saleh,Ben Clock,Devin E Gibbs, Mandee Yang,Shahab Younesi,Lily Gane, Victor Gutierrez-Garcia,Haibin Xi,April D Pyle
Nature cell biologyno. 12 (2023): 1758-1773
Development (Cambridge, England)no. 14 (2023)
Michael R. Emami,Courtney Young,Xinjun Zhang,Giorgia Del Vecchio, Cloelia Decioccio, Ana Orlowsky,April D. Pyle,Melissa J. Spencer
MOLECULAR THERAPYno. 4 (2023): 233-233
Cited0Views0Bibtex
0
0
MOLECULAR THERAPYno. 4 (2023): 662-663
Cited0Views0Bibtex
0
0
Michael R. Emami, Alejandro Espinoza,Courtney S. Young,Feiyang Ma,Philip K. Farahat,Philip L. Felgner,Jeffrey S. Chamberlain, Xiangmin Xu,April D. Pyle,Matteo Pellegrini,S. Armando Villalta,Melissa J. Spencer
Molecular Therapy - Methods & Clinical Development (2023): 90-102
H. Chen, M. Emami, C. Young, X. Zhang, Vecchio G. Del, T. Rando, R. Jimenez, B. Frietas,A. Pyle, O. Ikotun, M. Spencer
NEUROMUSCULAR DISORDERS (2023): S216-S216
Cited0Views0Bibtex
0
0
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn