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Research Summary
In our laboratory we investigate the gene regulatory code that shapes vertebrate embryonic development using zebrafish as a model system. We combine genomics, genetics, embryology, machine learning and computational biology to address a central question in biology: how does a fertilized egg develop into a complex multicellular embryo. This process requires a precise spatial and temporal regulation of gene expression. We are primarily focus on understanding i) the mechanisms that activate the genome after fertilization, ii) the post-transcriptional regulatory code that shapes mRNA stability and translation across vertebrates using the maternal to zygotic transition as a model, and iii) the gene regulatory code that specifies different cell types during embryogenesis. Our research is focusing in four main areas: Mechanisms of Genome activation, mechanisms of post-transcriptional regulation, computational modeling of gene expression and animal models to understand autism.
Research Interests
Developmental Biology; Gene Expression Regulation, Developmental; Computational Biology; Genomics; Systems Biology; Autism Spectrum Disorder; RNA Recognition Motif
In our laboratory we investigate the gene regulatory code that shapes vertebrate embryonic development using zebrafish as a model system. We combine genomics, genetics, embryology, machine learning and computational biology to address a central question in biology: how does a fertilized egg develop into a complex multicellular embryo. This process requires a precise spatial and temporal regulation of gene expression. We are primarily focus on understanding i) the mechanisms that activate the genome after fertilization, ii) the post-transcriptional regulatory code that shapes mRNA stability and translation across vertebrates using the maternal to zygotic transition as a model, and iii) the gene regulatory code that specifies different cell types during embryogenesis. Our research is focusing in four main areas: Mechanisms of Genome activation, mechanisms of post-transcriptional regulation, computational modeling of gene expression and animal models to understand autism.
Research Interests
Developmental Biology; Gene Expression Regulation, Developmental; Computational Biology; Genomics; Systems Biology; Autism Spectrum Disorder; RNA Recognition Motif
研究兴趣
论文共 36 篇作者统计合作学者相似作者
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biorxiv(2022)
Anna-Sophia Boguraev, Holly C. Christensen,Ashley R. Bonneau, John A. Pezza,Nicole M. Nichols,Antonio J. Giraldez,Michelle M. Gray,Brandon M. Wagner, Jordan T. Aken,Kevin D. Foley,D. Scott Copeland,Sebastian Kraves,
Anna-Sophia Boguraev, Holly C. Christensen,Ashley R. Bonneau, John A. Pezza,Nicole M. Nichols,Antonio J. Giraldez, Michelle M. Gray,Brandon M. Wagner, Jordan T. Aken,Kevin D. Foley,D. Scott Copeland,Sebastian Kraves,
npj Microgravityno. 1 (2018)
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