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个人简介
During the last 30 years, I have developed an expertise in the pathophysiology of epilepsy and the development of animal models. When in Strasbourg, I actively participated in the validation of the Genetic Absence Epilepsy Rat from Strasbourg (GAERS) and I am now in charge of the maintenance of this strain. Using this model and others, I characterized the control of epileptic seizures by the basal ganglia and this concept has led to several clinical validations and applications for neurostimulation. Since my move to Grenoble in 2003, I created a translation research group composed of clinicians and biologists (n=12-20) which is dedicated to the understanding of epilepsy and the development of new therapies. In particular, we have developed a new model of mesiotemporal lobe epilepsy in the mouse and have characterized its electroclinical, histological and pharmacological similarities with the human pathology. I have obtained fundings and have coordinated several successful and productive research projects involving colleagues with different expertises.
研究兴趣
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Alexandre Bacq,Antoine Depaulis, Vincent Castagné,Marie-Emmanuelle Le Guern,Elaine C. Wirrell,Marc Verleye
PROGRESS IN NEUROBIOLOGY (2024): 102564-102564
Nature communicationsno. 1 (2023): 1531
Revue Neurologique (2022)
Célia Lentini,Marie d'Orange,Nicolás Marichal, Marie-Madeleine Trottmann,Rory Vignoles,Louis Foucault, Charlotte Verrier, Céline Massera,Olivier Raineteau,Karl-Klaus Conzelmann,Sylvie Rival-Gervier,Antoine Depaulis,
Cell stem cellno. 12 (2021): 2104-2121.e10
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