基本信息
浏览量:7
职业迁徙
个人简介
Nanaline H. Duke Distinguished Professor Emeritus of Pharmacology, in the School of Medicine
The Means laboratory is interested in the study of cell signaling cascades that regulate cell proliferation, differentiation or function and how alterations in these pathways contribute to disease states. It is hoped that an understanding of these pathways may provide clues to novel targets that may be amenable to the drug discovery process. Current major research projects under investigation include:
1. The cellular mechanisms that govern regulation of CaMKIV, the CaM cascade, which includes CaMKK, CaMK1, CaMKIV and AMPK, and how these calcium-mediated signaling cascade affects cell function fate decisions. Examples of current studies include apoptosis, differentiation, self-renewal of stem cells and central regulation of energy balance.
2. Evaluating the pathways that are involved in regulating cell migration and invasiveness. One project investigates the protein kinase MLK3 and how it is involved in the cascade of events by which small G proteins such as Cdc42, Rac and Rho control directed cell movements via changes in the cytoskeleton.
3. Examining the role of the prolyl isomerase Pin1 in oncogenesis. Studies are focused on the Ras-mediated pathways involving Pin1 that control accumulation of oncoproteins such as Myc and cyclin E and how these pathways participate in human cell transformation and tumorigenesis.
研究兴趣
论文共 522 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Daniel E. Frigo, Matthew K. Howe, Bryan M. Wittmann, Abigail M. Brunner, Ian Cushman,Qianben Wang,Myles Brown,Anthony R. Means,Donald P. McDonnell
crossref(2023)
semanticscholar(2016)
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn