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个人简介
I graduated with a B.S. in Biology from Willamette University (Salem, Oregon, USA), and a Ph.D. in Genetics and Molecular Biology from the University of North Carolina at Chapel Hill (USA). At UNC-CH I was a member of Jack Griffith’s lab in the Lineberger Comprehensive Cancer Center. Thereafter, I trained as a USA National Science Foundation International Research Fellow with Roger Reddel at the Children's Medical Research Institute (CMRI) in Sydney, Australia and a USA National Institutes of Health Ruth L. Kirschstein NRSA Fellow with Jan Karlseder at the Salk Institute (La Jolla, California, USA). I returned to Sydney in June 2013 to establish my independent laboratory at CMRI with the assistance of a Cancer Institute NSW Future Research Leader Award.
I am known for a series of discoveries related to “telomeres”: the specialized structures that delineate the naturally occurring DNA ends from DNA breaks. This includes the discovery that telomeres interact with the DNA damage response machinery during ageing to arrest cell growth whilst simultaneously inhibiting aberrant DNA repair at chromosome ends. Subsequent discoveries include how telomeres specifically inhibit activation of the DNA damage response by hiding the chromosome end in a lariat structure called a “telomere-loop (t-loop)”; that t-loops are opened during mitotic arrest through a mechanism of non-canonical telomere deprotection to promote cell death; and collaborative studies showing how t-loops are resolved in a cell cycle dependent manner to promote telomeric DNA replication. My lab continues to study telomere biology using advanced imaging and mass spectrometry methods.
My laboratory also studies broader aspects of genome stability. This includes projects that focus on the cellular response to difficulties that arise during DNA replication; the unique burdens embryonic stem cells face related to maintaining genomic health; how alteration of nuclear and chromatin architecture promotes genome stability; and how chemotherapeutic or radiation-oncology intervention promotes cancer cell death.
研究兴趣
论文共 75 篇作者统计合作学者相似作者
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Sile F. Yang, Christopher B. Nelson, Jadon K. Wells,Madushan Fernando,Robert Lu,Joshua A. M. Allen, Lisa Malloy,Noa Lamm,Vincent J. Murphy,Joel P. Mackay,Andrew J. Deans,Anthony J. Cesare,
Nature Communicationsno. 1 (2024): 1-15
Diana Romero-Zamora,Samuel Rogers,Ronnie Ren Jie Low, Andrew B. Robinson,Scott G. Page, Blake J. E. Lane,Noa Lamm,Fuyuki Ishikawa,Makoto T. Hayashi,Anthony J. Cesare
biorxiv(2024)
Ashley Harman,Melissa Kartawinata, Nohad M. Maroun, Darren R. Nguyen,William E. Hughes, Kevin Winardi,Anthony J. Cesare,Noa Lamm,Tracy M. Bryan
crossref(2024)
Radoslaw Szmyd, Sienna Casolin, Lucy French, Anna Gonzalez Manjon,Andrew Dhawan,Christopher B. Nelson, Léa Cavalli,Scott G. Page,Eric Hau,Hilda A. Pickett,Harriet E. Gee,Anthony J. Cesare
crossref(2024)
biorxiv(2023)
crossref(2023)
Cell chemical biologyno. 12 (2023): 1652-1665.e6
crossref(2023)
crossref(2023)
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