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Heat shock protein 60 kDa (hsp60) gene sequences in infectious disease diagnosis, microbial identification, phylogeny and pathogenesis: Two key observations from my laboratory led to the development of several patented diagnostic technologies: a) hsp60 genes from different organisms have both highly conserved as well as species-specific sequences; and b) universal hsp60 degenerate primers can amplify a 600-bp gene product from any microorganism of interest. These discoveries enabled us to develop novel approaches for the genotypic detection and accurate identification of fastidious and nonculturable pathogens, phylogenetic analysis of emerging pathogens, and the investigation of recombinant hsp60 peptides in the serodiagnosis and immunopathogenesis of infectious diseases.
Molecular pathogenesis and clinical spectrum of staphylococcal toxic shock syndrome (TSS): These studies include the clinical spectrum and epidemiology of TSS; pathogenesis and animal models of TSS: clonality and genotyping of S. aureus- structure/function analysis and genetic regulation of TSS-associated staphylococcal toxins- mechanisms and signaling pathways of microbial superantigens. These studies have led to invitations as a key-note speaker and session chairman for several International Symposia on Toxic Shock Syndrome (1987 and 1997), Gordon Research Conference on Staphylococcal Diseases (1993), the International Congress of Chemotherapy Symposium on Staphylococcal Virulence (1995) and the Canadian Association of Medical Microbiology and Infectious Diseases Symposium on Staphylococcal Virulence (1996), and as a member of the site-visit team to review the US Army Medical Research Program on Toxins (2002).
Heat shock protein 60 kDa (hsp60) gene sequences in infectious disease diagnosis, microbial identification, phylogeny and pathogenesis: Two key observations from my laboratory led to the development of several patented diagnostic technologies: a) hsp60 genes from different organisms have both highly conserved as well as species-specific sequences; and b) universal hsp60 degenerate primers can amplify a 600-bp gene product from any microorganism of interest. These discoveries enabled us to develop novel approaches for the genotypic detection and accurate identification of fastidious and nonculturable pathogens, phylogenetic analysis of emerging pathogens, and the investigation of recombinant hsp60 peptides in the serodiagnosis and immunopathogenesis of infectious diseases.
Molecular pathogenesis and clinical spectrum of staphylococcal toxic shock syndrome (TSS): These studies include the clinical spectrum and epidemiology of TSS; pathogenesis and animal models of TSS: clonality and genotyping of S. aureus- structure/function analysis and genetic regulation of TSS-associated staphylococcal toxins- mechanisms and signaling pathways of microbial superantigens. These studies have led to invitations as a key-note speaker and session chairman for several International Symposia on Toxic Shock Syndrome (1987 and 1997), Gordon Research Conference on Staphylococcal Diseases (1993), the International Congress of Chemotherapy Symposium on Staphylococcal Virulence (1995) and the Canadian Association of Medical Microbiology and Infectious Diseases Symposium on Staphylococcal Virulence (1996), and as a member of the site-visit team to review the US Army Medical Research Program on Toxins (2002).
Research Interests
Papers共 329 篇Author StatisticsCo-AuthorSimilar Experts
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2024)
Heart Rhythmno. 5 (2024): S723
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2024)
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2024)
Heart rhythm (2024)
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2024)
Christopher Monkhouse, Sufna Fazil, Jincymol Binoy, Helen Harvie, Hollie Granville, William Proctor, Edward Maclean,Richard Schilling,Anthony Chow,Malcolm Finlay,Shohreh Honarbakhsh,Ross Hunter,
Heart Rhythm (2024)
George Katritsis,Balrik Kailey,Vishal Luther, Shahnaz Jamil Copley,Michael Koa-Wing, Anu Balasundram,Louisa Malcolme-Lawes,Norman Qureshi,Phang Boon Lim,Fu Siong Ng, Nuno Cortez Diaz,Luis Carpinteiro,
HEART RHYTHMno. 5 (2024): 571-580
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGYno. 3 (2024): e012446-e012446
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Author Statistics
#Papers: 329
#Citation: 12791
H-Index: 49
G-Index: 106
Sociability: 7
Diversity: 3
Activity: 22
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