基本信息
views: 1
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
Professor Stephenson’s molecular neuroscience research group aims to elucidate fundamental mechanisms which contribute to the molecular organization of synapses. She studies mechanisms of mitochondrial transport following her discovery of the TRAK family of kinesin adaptor proteins, key mediators of mitochonbdrial trafficking. Also, her group study neurotransmitter receptors and their associated scaffolding proteins aspiring to understand how protein-protein interactions determine that neurones ensure that appropriate numbers of a particular neurotransmitter receptor subtype with unique pharmacological and biophysical properties are trafficked and targeted to a defined subcellular localization to ensure fidelity of brain function. Both inhibitory and excitatory synapses are studied focusing on GABAA receptors and the NMDA subclass of excitatory L-glutamate receptors respectively. Both receptors are complex, heteromeric, allosterically modulated integral membrane proteins that are implicated in neurological disease: NMDA receptor dysfunction in stroke, neuropathic pain, epilepsy, Alzheimer’s Disease, and schizophrenia whereas GABAA receptor dysfunction is associated with epilepsy, anxiety and panic disorders.
Research Interests
Papers共 70 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
ACS MEDICINAL CHEMISTRY LETTERSno. 4 (2023): 442-449
Journal of Biological Chemistryno. 12 (2022): 102590-102590
Brain and neuroscience advances (2019): 2398212819858249-2398212819858249
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn