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个人简介
In the Nørremølle research group our goal is to understand the pathogenic mechanisms causing the cellular damage in inherited neurodegenerative disorders, with specific focus on Huntington disease. In this disease, despite a well-characterized disease-causing mutation, neither the physiological functions nor the mechanisms behind the pathological changes are known.
Current research
Right now we concentrate on investigating the metabolic changes observed in both neuronal and non-neuronal cell types in Huntington disease cell and animal models. We study mitochondrial function and oxidative stress in order to understand the importance of these processes in the disease, and aiming to characterize new targets for future treatment strategies.
In another line of research, we analyze the DNA sequence of the huntingtin gene region in Danish patients with Huntington disease, looking for DNA variants that modify the disease onset or progression. The rationale is that genes carrying these variants represent possible targets for treatment: modifying the modifiers.
In addition to our work in Huntington disease research we participate in collaborations investigating other inherited neurodegenerative disorders.
Current research
Right now we concentrate on investigating the metabolic changes observed in both neuronal and non-neuronal cell types in Huntington disease cell and animal models. We study mitochondrial function and oxidative stress in order to understand the importance of these processes in the disease, and aiming to characterize new targets for future treatment strategies.
In another line of research, we analyze the DNA sequence of the huntingtin gene region in Danish patients with Huntington disease, looking for DNA variants that modify the disease onset or progression. The rationale is that genes carrying these variants represent possible targets for treatment: modifying the modifiers.
In addition to our work in Huntington disease research we participate in collaborations investigating other inherited neurodegenerative disorders.
研究兴趣
论文共 72 篇作者统计合作学者相似作者
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Luisana Duque Villegas,Abinaya Chandrasekaran, Sofie Amalie Flintholm Andersen,Anne Norremolle,Benjamin Schmid,Mahmoud A. Pouladi,Kristine Freude
Stem cell research (2024): 103408-103408
A: Pathogenic mechanisms (2022): A12-A12
Journal of Neurology, Neurosurgery, and Psychiatry (2021): A4-A4
Sara Bech,Annemette Lokkegaard,Troels T. Nielsen,Anne Norremolle,Sabine Gronborg,Lis Hasholt, Gudrun K. Steffensen,Gabor Graehn, Jess H. Olesen,Niels Tommerup,Yuan Mang,Mads Bak,
Sara Bech,Annemette Løkkegaard,Troels T. Nielsen,Anne Nørremølle,Sabine Grønborg,Lis Hasholt, Gudrun K. Steffensen,Gabor Graehn, Jess H. Olesen,Niels Tommerup,Yuan Mang,Mads Bak,
Movement Disordersno. 12 (2020): 2343-2347
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作者统计
#Papers: 72
#Citation: 1615
H-Index: 23
G-Index: 39
Sociability: 6
Diversity: 3
Activity: 7
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