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While much of the study of the life sciences has been empirical in nature, the field continues to evolve into a science that is founded on fundamental physical principles. Understanding how physical principles apply to biological systems will allow predictive understanding of these complex processes. In addition, better fundamental understanding will help to make the manufacturing of advanced therapy products more efficient and reliable.
Our current research focuses on single-cell measurements from live cell microscopy, and development of theoretical approaches that lead to predictive understanding of complex cellular systems. Currently, we are examining small molecular networks in engineered induced pluripotent stem cells with a statistical thermodynamics model. The heterogeneity of cellular phenotypes within isogenic populations provides a window into the diversity of ways the cellular machinery can operate to process information. This diversity of expression reflects the stochastic fluctuations that occur as connected network variables interact with one another to effect up- and down-regulation.
Our current research focuses on single-cell measurements from live cell microscopy, and development of theoretical approaches that lead to predictive understanding of complex cellular systems. Currently, we are examining small molecular networks in engineered induced pluripotent stem cells with a statistical thermodynamics model. The heterogeneity of cellular phenotypes within isogenic populations provides a window into the diversity of ways the cellular machinery can operate to process information. This diversity of expression reflects the stochastic fluctuations that occur as connected network variables interact with one another to effect up- and down-regulation.
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Peter Bajcsy, Sreenivas Bhattiprolu,Katy Boerner,Beth A Cimini,Lucy Collinson,Jan Ellenberg, Reto Fiolka, Maryellen Giger,Wojtek Goscinski,Matthew Hartley,Nathan Hotaling,Rick Horwitz,
arxiv(2024)
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Anthony J Asmar,Zackery A Benson,Adele P Peskin,Joe Chalfoun,Mylene Simon,Michael Halter,Anne L Plant
bioRxiv (Cold Spring Harbor Laboratory)no. 2 (2024): e0298446-e0298446
SSRN Electronic Journal (2022)
Bioinformatics, Computational Biology and Biomedicinepp.1-7, (2022)
Cell Therapypp.609-625, (2021)
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