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A cancer molecular biologist, Anne Dejean investigates the molecular and cellular mechanisms involved in the development of human cancers. She discovered that retinoic acid receptor (RAR) genes are mutated in liver cancer and a rare type of leukemia and deciphered the molecular and cellular bases for the cure of this leukemia, opening up unique perspectives for new differentiation and anti-tumor targeted therapy leads. She first found such a mutation in HBV-associated liver cancer, demonstrating that this virus, by inserting its genome into that of the hepatic cell, can disrupt neighbouring human genes and directly trigger the development of liver cancer. This discovery led A. Dejean’s team to clone the RARb gene and identify the first responsive element to retinoic acid. They then discovered the PML-RARa oncogenic fusion protein as the causative genetic event in acute promyelocytic leukemia (APL), dissected its oncogenic properties and elucidated the mechanims underlying the cure of APL by retinoic acid and arsenic, a treatment that remains the most efficient oncogene-targeted therapy described so far. Anne Dejean then demonstrated that a particular sub-nuclear structure, the PML Nuclear Body, is disrupted in APL and showed that both retinoic acid and arsenic are able to correct this cellular defect. She then showed that arsenic induces the post-translational modification of PML-RARa by the small SUMO protein as well as the degradation of the oncoprotein in APL.
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论文共 85 篇作者统计合作学者相似作者
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Cancer Researchno. 3 (2023): 901-910
Agnès Marchio,Christophe Batejat,Jessica Vanhomwegen,Maxence Feher,Quentin Grassin,Maxime Chazal, Olivia Raulin, Anne Farges-Berth,Florence Reibel, Vincent Estève,Anne Dejean,Nolwenn Jouvenet,
Müge Ogrunc,Ricardo Ivan Martinez-Zamudio, Paul Ben Sadoun, Gregory Dore, Helene Schwerer,Philippe Pasero,Jean-Marc Lemaitre,Anne Dejean,Oliver Bischof
Cell reportsno. 8 (2021): 108786
Nitin Agarwal,Francisco J Taberner, Daniel Rangel Rojas,Mirko Moroni, Damir Omberbasic,Christian Njoo,Alexandra Andrieux,Pooja Gupta,Kiran K Bali,Esther Herpel,Faramarz Faghihi,Thomas Fleming,
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