基本信息
浏览量:2
职业迁徙
个人简介
Current Research and Scholarly Interests
Varicella-zoster virus (VZV) causes varicella (chickenpox) and zoster (shingles). Our laboratory investigates the molecular virology ofvzv, focusing on the functional roles of particular viral gene products in pathogenesis and virus-cell interactions in differentiated human cells in SCID mouse models ofVzV infection in vivo.Aspects of VZV tropism are investigated using SCID mice that have human skin, T cell and dorsal root ganglion xenografts and VZV recombinant viruses that have targeted mutations of viral promoters,open reading frames and non-codingregions.The consequences of targeted mutations in the VZV genome reveal functions that are important for VZV pathogenesis and that counteract intrinsic cellular regulation ot VZV replication. These studies provide information relevant for developing new genetically engineered vaccines to reduce the disease burden of VZV infections.
研究兴趣
论文共 41 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Rachel Wong,Hasan Imam,Julia Di Iulio, Amin Momin, Yi-Pei Chen,Andrea L. Cathcart,Gregory Camus,Andre Arizpe,Sneha Gupta, David Sun,Daniel Cloutier,Ann Arvin,
HEPATOLOGY (2023): S605-S607
引用0浏览0引用
0
0
NATURE COMMUNICATIONSno. 1 (2023): 7958-7958
semanticscholar(2021)
Science Translational Medicineno. 568 (2020)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn