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个人简介
Current Research and Scholarly Interests
Our laboratory's current transformative research efforts focus on studying immune health in the context of surgery and anesthesia. Our interest stems from previous work elucidating the modulation of inflammatory responses by anesthetic and analgesic drugs.
The aim of studying immunity in patients undergoing surgery is to identify immune phenotypes predictive of aversive postoperative outcomes including protracted recovery and infection. Our major working hypotheses are that 1) specific immune phenotypes will predict the risk for developing postoperative complications, 2) immune phenotyping will lead to the discovery of mechanisms aggravating or alleviating such risk, and 3) gained knowledge will allow devising immune-modulatory strategies mitigating such risk. Mass cytometry (CyTOF), proteomics, and functional ex-vivo immune assays are the major molecular tools for the systems-based numerical and functional exploration of the circulating immune system.
Our laboratory's current transformative research efforts focus on studying immune health in the context of surgery and anesthesia. Our interest stems from previous work elucidating the modulation of inflammatory responses by anesthetic and analgesic drugs.
The aim of studying immunity in patients undergoing surgery is to identify immune phenotypes predictive of aversive postoperative outcomes including protracted recovery and infection. Our major working hypotheses are that 1) specific immune phenotypes will predict the risk for developing postoperative complications, 2) immune phenotyping will lead to the discovery of mechanisms aggravating or alleviating such risk, and 3) gained knowledge will allow devising immune-modulatory strategies mitigating such risk. Mass cytometry (CyTOF), proteomics, and functional ex-vivo immune assays are the major molecular tools for the systems-based numerical and functional exploration of the circulating immune system.
研究兴趣
论文共 228 篇作者统计合作学者相似作者
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Frontiers in allergy (2024): 1373485-1373485
bioRxiv : the preprint server for biology (2024)
npj Digital Medicineno. 1 (2023)
Frontiers in allergy (2023): 1149008
Research square (2023)
Alexandra Neville,Emma Biggs, Alexandra Tremblay-McGaw, Amanda Wiseman Miner,Robert Coghill,Christopher King,Marina Lopez-Sola,Massieh Moayedi,Brice Gaudilliere,Nima Aghaeepour,Martin Angst,Jennifer Stinson,
JOURNAL OF PEDIATRIC PSYCHOLOGY (2023): 144-145
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The Journal of thoracic and cardiovascular surgeryno. 2 (2023): 559-568.e6
Nature computational scienceno. 4 (2023): 346-359
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作者统计
#Papers: 226
#Citation: 10962
H-Index: 53
G-Index: 102
Sociability: 7
Diversity: 0
Activity: 1
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