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Bio
My laboratory is involved in the study of the molecular mechanisms at the basis of motor neuron diseases (MNDs). Our main focus is on two forms of MNDs named spinal and bulbar muscular atrophy (SBMA) and amyotrophic lateral sclerosis (ALS), which are associated to the formation of aberrant mutant protein conformations that, for this, become neurotoxic. Our major aims are those to boost the intracellular protein quality control system to clear neurotoxic protein from affected neuronal cells. We recently identified a protective effect of a small heat shock protein (HSPB8) in the two diseases. This action seems to be mediated by the activation of autophagy.
We have also projects on prostate and breast cancers in which we have described the antiproliferative, antimetastatic action of an androgenic metabolite, the 3beta-diol, which exert this protective role via the activation of an estrogenic pathway, as well as the role of autophagy and HSPB8 in these context.
Awards, Distinctions
2013-... Director of the PhD program in Endocrinological and Metabolic Sciences, Università degli Studi di Milano, Italy
2014-...Coordinator of Section of Biomedicine and Endocrinology (DiSFeB/UNIMI)
Awards and Other Professional Activities
- Chiodini’s Award for the studies in Neuroendocrinology
- Member of the Steering Committee and of the Scientific Board of the Center of Excellence on Neurodegenerative Diseases of the University of Milan, Italy
- Member of the Steering Committee of the InterUniversity Center on Neurodegenerative Diseases: Universities of Florence, Rome (Tor Vergata), Genoa and Milan, Italy
- Member of the Steering Committee of the Italian Society for Neuroscience (SINS)
We have also projects on prostate and breast cancers in which we have described the antiproliferative, antimetastatic action of an androgenic metabolite, the 3beta-diol, which exert this protective role via the activation of an estrogenic pathway, as well as the role of autophagy and HSPB8 in these context.
Awards, Distinctions
2013-... Director of the PhD program in Endocrinological and Metabolic Sciences, Università degli Studi di Milano, Italy
2014-...Coordinator of Section of Biomedicine and Endocrinology (DiSFeB/UNIMI)
Awards and Other Professional Activities
- Chiodini’s Award for the studies in Neuroendocrinology
- Member of the Steering Committee and of the Scientific Board of the Center of Excellence on Neurodegenerative Diseases of the University of Milan, Italy
- Member of the Steering Committee of the InterUniversity Center on Neurodegenerative Diseases: Universities of Florence, Rome (Tor Vergata), Genoa and Milan, Italy
- Member of the Steering Committee of the Italian Society for Neuroscience (SINS)
Research Interests
Papers共 293 篇Author StatisticsCo-AuthorSimilar Experts
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MOLECULAR ONCOLOGYno. 8 (2024): 1966-1979
Jiayan Tan, Han Duong,Margherita Milone, Liliane Gibbs, Barbara Tedesco,Angelo Poletti, Virginia Kimonis
crossref(2024)
JOURNAL OF NEUROCHEMISTRY (2023): 103-103
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Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeuticsno. 2 (2023): 524-545
Riccardo Cristofani,Nausicaa V. Licata,Sally Salomonsson, Paola Pramaggiore, Katherine M. Wilson, Liam Kempthorne,Deniz Vaizoglu,Vito G. D'Agostino, Daniele Pollini, Rosa Loffredo, Michael Pancher, Valentina Adami,
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CELLSno. 8 (2022)
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