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Scanu, a renowned expert on lipoprotein(a), was the first to show that the structure of Lp(a) closely resembles plasminogen, an agent involved in dissolving blood clots. This 1987 discovery indicated that Lp(a) can compete with plasminogen, preventing the removal of clots. This led to blocked arteries and heart attacks.
A series of studies led by Scanu gradually persuaded heart and vascular specialists around the world that certain variants of Lp(a) were strongly associated with an increased risk of coronary artery disease. By 2009, more than 20 years after Scanu’s team first described the mechanism, data from multiple studies were able to “support a causal role of Lp(a) lipoprotein in coronary disease,” according to a study published in the New England Journal of Medicine.
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