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My research focus is on understanding how structurally complex natural products are constructed by soil-dwelling bacteria.
Genetic, biochemical and chemical techniques are used to determine how molecules with unusual structures are biosynthesised, and we are developing methods to reprogram pathways to produce novel natural product-like molecules. A vast array of medicines are produced by soil-dwelling bacteria, and the discovery of new pathways will support the development of future drugs.
We are examining a variety of natural products, including non-ribosomal peptides like vancomycin, which is a drug of last resort to treat methicillin-resistant Staphylococcus aureus (MRSA) infections, and ribosomally synthesised and post-translationally modified peptides (RiPPs), such as bottromycin. This is a clinically promising and structurally unique RiPP that is active towards multi-drug resistant bacteria, such as MRSA. In addition, the analysis of genomic data has revealed that bacteria have an untapped potential to produce secondary metabolites, and key pathways are being investigated.
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论文共 47 篇作者统计合作学者相似作者
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Methods in molecular biology (Clifton, N.J.) (2021): C1-C1
Alba Pacheco-Moreno,Francesca L Stefanato, Jonathan J Ford,Christine Trippel,Simon Uszkoreit,Laura Ferrafiat,Lucia Grenga,Ruth Dickens,Nathan Kelly, Alexander DH Kingdon,Liana Ambrosetti,Sergey A Nepogodiev,
eLife (2021)
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