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个人简介
Professor Andrew Spencer is Head of the Malignant Haematology and Stem Cell Transplantation Service at The Alfred Hospital, Professor of Haematology at Monash University, Head of the Myeloma Research Group and Co-Director of the ACRF Blood Cancer Therapeutics Centre at the Australian Centre for Blood Diseases, all in Melbourne, Australia.
Prof Spencer has 185 peer reviewed publications with citations in excess of 12,600 and holds 4 international patents in multiple myeloma (MM) therapeutics. Since 2013 he has been an invited speaker at 40 international meetings on genomics, therapeutics and disease monitoring in MM and is an invited investigator of the International Myeloma Foundation (IMF) Black Swan Research Initiative devising and implementing global minimal residual disease strategies for MM. He serves on the scientific advisory boards of the IMF and the International Myeloma Working Group. He chairs the Myeloma and Related Diseases Registry that he established in 2012 and the Australasian Myeloma Research Consortium. He sits on the steering committee for the global MM registry initiative INSIGHT.
Research interests
The research program of Professor Andrew Spencer aims to:
(1) identify more effective and rationale novel therapeutic strategies for MM through the identification of drug resistance processes and/or biomarkers of drug responsiveness (employing transcriptional and proteomic studies in mouse models and primary tumours) with rapid translational of synergistic drug combinations into early phase investigator-initiated clinical trials, and
(2) identify mechanisms of MM disease progression, with a particular focus on the role of the cell surface phosphatase CD45, and
(3) explore the role of different modalities of minimal residual disease (MRD) detection in MM to optimise their utility in clinical practice.
Prof Spencer has 185 peer reviewed publications with citations in excess of 12,600 and holds 4 international patents in multiple myeloma (MM) therapeutics. Since 2013 he has been an invited speaker at 40 international meetings on genomics, therapeutics and disease monitoring in MM and is an invited investigator of the International Myeloma Foundation (IMF) Black Swan Research Initiative devising and implementing global minimal residual disease strategies for MM. He serves on the scientific advisory boards of the IMF and the International Myeloma Working Group. He chairs the Myeloma and Related Diseases Registry that he established in 2012 and the Australasian Myeloma Research Consortium. He sits on the steering committee for the global MM registry initiative INSIGHT.
Research interests
The research program of Professor Andrew Spencer aims to:
(1) identify more effective and rationale novel therapeutic strategies for MM through the identification of drug resistance processes and/or biomarkers of drug responsiveness (employing transcriptional and proteomic studies in mouse models and primary tumours) with rapid translational of synergistic drug combinations into early phase investigator-initiated clinical trials, and
(2) identify mechanisms of MM disease progression, with a particular focus on the role of the cell surface phosphatase CD45, and
(3) explore the role of different modalities of minimal residual disease (MRD) detection in MM to optimise their utility in clinical practice.
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Blood advancesno. 2 (2024): 388-398
Mara N. Zeissig,Duncan R. Hewett, Krzysztof M. Mrozik,Vasilios Panagopoulos, Craig T. Wallington-Gates,Andrew Spencer, Sandra M. Dold,Monika Engelhardt,Kate Vandyke,Andrew C.W. Zannettino
Leukemia Research (2024): 107469-107469
James Schwarer, Joanne B. L. Tan, BIanca Cirone, Lily Rush,Jenny Muirhead,Shu Min Wong,Shafqat Inam,Shaun Fleming,Sushrut S. Patil, C. Orla Morrissey,John Coutsouvelis,Andrew Spencer,
Cancer Researchno. 7_Supplement (2023): 2366-2366
Ola Landgren,Ajai Chari,Yael C. Cohen,Andrew Spencer,Peter M. Voorhees,Irwindeep Sandhu,Matthew W. Jenner, Dean Smith,Michele Cavo, Niels WCJ van de Donk,Meral Beksac,Philippe Moreau,
Bloodno. Supplement 1 (2023): 210-210
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