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Our work is concerned with mitochondrial function; how this is altered in metabolic diseases, during development and ageing, and with changes in diet, exercise and oxygen; and what effects these changes have on physiological performance. We aim to elucidate the causes of mitochondrial dysfunction and the impact this has on function at the level of the tissue, intact organ and whole body.
Our interest lies in the control of mitochondrial respiration and energy metabolism. We are interested in the metabolic response to dietary manipulation and alterations in oxygen supply, including the matching of oxygen demand and supply. We study this in cells, tissues, animal models and healthy humans at high altitude, and in relation to diseases such as heart failure, COPD, anaemia and pathologies of pregnancy such as preeclampsia. A major recent interest is the role of dietary nitrate in the regulation of metabolism.
Our interest lies in the control of mitochondrial respiration and energy metabolism. We are interested in the metabolic response to dietary manipulation and alterations in oxygen supply, including the matching of oxygen demand and supply. We study this in cells, tissues, animal models and healthy humans at high altitude, and in relation to diseases such as heart failure, COPD, anaemia and pathologies of pregnancy such as preeclampsia. A major recent interest is the role of dietary nitrate in the regulation of metabolism.
Research Interests
Papers共 200 篇Author StatisticsCo-AuthorSimilar Experts
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SCIENCE ADVANCESno. 6 (2024)
Science advancesno. 6 (2024): eadj5661-eadj5661
Joycelyn Tan,Sam Virtue,Dougall M. Norris,Olivia J. Conway,Ming Yang,Guillaume Bidault,Christopher Gribben, Fatima Lugtu,Ioannis Kamzolas,James R. Krycer,Richard J. Mills, Lu Liang,
EMBO JOURNALno. 11 (2024): 2127-2165
Alice P. Sowton,Lorenz M.W. Holzner, Fynn N. Krause, Ruby Baxter,Gabriele Mocciaro, Dominika K. Krzyzanska,Magdalena Minnion, Katie A. O’Brien, Matthew C. Harrop, Paula M. Darwin, Benjamin D. Thackray, Michele Vacca,
biorxiv(2024)
Anthony I Shepherd, Thomas J James, Alex A M Gould,Harry Mayes,Rebecca Neal,Janis Shute,Michael J Tipton,Heather Massey,Zoe L Saynor,Maria Perissiou,Hugh Montgomery, Connie Sturgess,
The Journal of physiology (2024)
MOLECULAR METABOLISM (2024): 101875-101875
Perioperative medicine (London, England)no. 1 (2023): 35
Joycelyn Tan,Sam Virtue,Dougall M. Norris,Olivia J. Conway,Ming Yang,Christopher Gribben, Fatima Lugtu,Ioannis Kamzolas,James R. Krycer,Richard J. Mills,Conceição Pereira,Martin Dale,
biorxiv(2023)
Katie A O'Brien,Wanjun Gu,Julie A Houck,Lorenz M W Holzner,Hong Wa Yung,Jenna L Armstrong,Alice P Sowton, Ruby Baxter, Paula M Darwin,Lilian Toledo-Jaldin,Litzi Lazo-Vega, Any Elena Moreno-Aramayo,
Hypertension (Dallas, Tex. : 1979)no. 2 (2023): 319-329
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