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My research aims to gain new molecular insights on the mechanisms of cell division and migration and how defects in these processes promote genetic instability and the invasive capacity of cancer cells. My major interest is in understanding how microtubule organization is regulated by the human NEK kinase family and how these enzymes control mitotic spindle assembly and remodelling of the cytoskeleton. I am keen to use this knowledge to develop novel precision medicines for cancer therapy with a particular focus on lung cancer. For this research I collaborate closely with biochemists structural biologists and clinical oncologists as well as seeking to work with industrial partners. I am the Principal Investigator for the Leicester Wellcome Trust Institutional Strategic Support Fund while my laboratory has received funding for my research from the Wellcome Trust Cancer Research UK BBSRC MRC Worldwide Cancer Research and Kidney Research UK.
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