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Bio
I am a pediatric cardiologist and cardiovascular geneticist with both clinical and research interests in the genetic and molecular mechanisms of sudden cardiac arrest in children. As a physician-scientist, I am trained at the confluence of pediatric cardiology, clinical electrophysiology, human genetics, and molecular biology which I apply towards the care for children with heritable arrhythmic disease of the heart. I run a basic science research lab exploring the genetic and molecular causes of sudden cardiac death in children and young adults. These include cardiomyopathies (hypertrophic cardiomyopathy, dilated cardiomyopathy, arrhythmogenic right ventricular dysplasia/cardiomyopathy) and channelopathies (long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, and short QT syndrome). In our lab, we utilize human induced pluripotent stem cells, mouse models, and in vitro cellular models of disease. Further, I have an active translational research interest in the interpretation of cardiovascular genetic testing and clarifying “variants of unknown significance”. Overall, I hope to 1) utilize human genetics and functional genomics to more accurately diagnosis, risk stratify, and treat children and young adults at risk for these diseases and 2) determine the underlying molecular mechanisms of these complex and deadly diseases to identify novel patient-specific therapies.
Research Interests
Papers共 165 篇Author StatisticsCo-AuthorSimilar Experts
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Melyssa Garner, Bansari Rajani, Priyanka Vaidya, Samer Abu Dayeh,Alana C Cecchi,Christina C Miyake, Vicki Huff, Matthew Wanat, Elisabeth Wang,Leonie M Kurzlechner,Andrew P Landstrom, Daniel An,
Research square (2024)
JACC: Advancesno. 2 (2024): 100767
Pediatric Cardiologyno. 5 (2024): 1-10
Pediatric cardiologypp.1-10, (2024)
Ghaith Sharaf Dabbagh, Kerrick Hesse, Ruchi Agnihotri, Gurpreet Kaur,Ravi Shah,Babken Asatryan,Kristian Galanti,Leonie M. Kurzlechner, Robert Pargament, Adnan Malik,Brian Schuler,Edmond K. Obeng-Gyimah,
Heart Rhythmno. 5 (2024): S177
Pediatric researchpp.1-7, (2024)
Heart Rhythmno. 5 (2023): S102-S102
Rebecca Koch,Claudia Soler-Alfonso,Bridget Kiely,Akihiro Asai, Ariana Smith,Deeksha Bali, Peter Kang,Andrew Landstrom,H. Orhan Akman,T. Andrew Burrow,Jennifer Orthmann-Murphy, Deberah Goldman,
Genetics in Medicine Openno. 1 (2023): 100114-100114
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