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My laboratory has developed a model of pancreatic cancer in the rat by implantation of the carcinogen DMBA in the pancreas. We are characterizing the genetic mutations which accumulate in the carcinogenesis sequence, attempting to develop from this tumor a cell line and tranplantable cancer in nude mice or inbred strains. We are using the model and other cells lines to study the mechanisms of action of chemotherapeutic agents. We are also trying to replicate the model in mice to allow the use of knockout technology as a tool for dissecting pathogenetic factors.
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Todd K Rosengart,Jennifer H Chen,Nancy L Gantt,Peter Angelos,Andrew L Warshaw,Jennifer E Rosen,Nancy D Perrier,Krista L Kaups,Gerard M Doherty, Theofano Zoumpou,Stanley W Ashley, William Doscher,
Annals of surgery (2024)
ANNALS OF SURGERYno. 2 (2024): 314-322
Global Surgical Education - Journal of the Association for Surgical Educationno. 1 (2023): 1-7
Annals of hepato-biliary-pancreatic surgery (2023)
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ANNALS OF HEPATO-BILIARY-PANCREATIC SURGERYno. 2 (2023): 195-200
International journal of cancerno. 1 (2023): 164-172
JCO oncology practiceno. 8 (2023): 551-+
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