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The research in my laboratory mainly investigates how pathogen interaction with the innate immune system influences the development of adaptive immunity and inflammation. My particular interest is Type 2 inflammation, which is responsible for widespread suffering in allergy, as well as being a hallmark of infection with parasitic worms (helminths).
Our research uses a combination of in vivo and in vitro model systems, focussing on the medically important helminth Schistosoma mansoni. Murine infection with this parasite provides a relevant experimental model of Type 2 inflammation that has been used extensively by my laboratory and others to reveal important cellular and molecular players and processes during hepatic, intestinal and pulmonary inflammation. Our current experimental focus in this area is on the immune features that dominate in the lungs and intestines at different stages of infection, and interplay between the parasite and the host microbiota.
Our research uses a combination of in vivo and in vitro model systems, focussing on the medically important helminth Schistosoma mansoni. Murine infection with this parasite provides a relevant experimental model of Type 2 inflammation that has been used extensively by my laboratory and others to reveal important cellular and molecular players and processes during hepatic, intestinal and pulmonary inflammation. Our current experimental focus in this area is on the immune features that dominate in the lungs and intestines at different stages of infection, and interplay between the parasite and the host microbiota.
Research Interests
Papers共 316 篇Author StatisticsCo-AuthorSimilar Experts
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Emma Louise Houlder,Sara Gago,George Vere,Daniel Conn,Saba Khan,Darren Thomson, Mark Shepherd, Ressa Lebedinec,Gordon D Brown,Michael Bromley,Andrew S MacDonald,Peter C Cook
biorxiv(2024)
Russell Hughes, Amy Moran,Karen J. Scott,Elizabeth Appleton,Matthew J. Bentham,Elizabeth Ilett,Alan Melcher,Andrew Macdonald,Adel Samson,Stephen Griffin
biorxiv(2024)
Molly R. Patterson, Aniek S. Meijers, Emma L. Ryder,James A. Scarth, Debra Evans,Amy L. Turner,Christopher W. Wasson, Janne E. Darell, Daisy Theobald, Joseph Cogan,Claire D. James, Miao Wang,
Oncogenepp.1-15, (2024)
Darren C Machin,Daniel J Williamson,Peter Fisher,Victoria J Miller,Zoe L P Arnott, Charlotte M E Stevenson,Gemma C Wildsmith, James F Ross,Christopher W Wasson,Andrew Macdonald, Benjamin I Andrews,Daniel Ungar,
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 1 (2024): 474
Molly R. Patterson, Joseph A. Cogan, Rosa Cassidy, Daisy A. Theobald, Miao Wang,James A. Scarth,Chinedu A. Anene, Adrian Whitehouse, Ethan L. Morgan,Andrew Macdonald
Nature Communicationsno. 1 (2024): 1-18
Emma Brown,Gemma Swinscoe,Daniella Lefteri, Ravi Singh, Amy Moran,Rebecca Thompson,Daniel Maskell, Hannah Beaumont,Matthew Bentham,Claire Donald,Alain Kohl,Andrew Macdonald,
bioRxiv (2024)
Virusesno. 1381 (2023): 1381
NATURE SUSTAINABILITYno. 6 (2023): 652-661
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