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个人简介
My academic background is highlighted by intensive training in nutritional biochemistry, environmental toxicology and structural biology. My long-term research interests are focused primarily on improving personalized-approaches to medicine and clarifying the environmental and molecular basis of common human diseases, including cancer, hypertension and obesity. I am considered an expert in the expression and purification of membrane-bound cytochrome P450 proteins for use in biochemical, biophysical and structural analysis studies, and I have significant experience in biological assay development using both in vivo and in vitro model systems. My early research involved the cloning, site-directed mutagenesis and biochemical characterization of drug- and hormone-metabolizing cytochrome P450 (CYP) enzymes, while my post-doctoral work was focused on complimentary structure/function studies exploiting x-ray crystallography, bioinformatics and structure-based drug design.
During my time at The Scripps Research Institute, I solved the first two high-resolution crystal structures for mitochondrial CYP forms (i.e. CYP11A1 & CYP24A1); these peripheral membrane proteins mediate key aspects of steroid hormone biosynthesis and metabolism, making them important drug targets for numerous disorders. Structural insights gained from these studies have significantly improved computational modeling for CYPs in this class. My long-term commitment to the CYP241 project rewarded me with a broad, technical skillset, highly applicable to research in Toxicology and Pharmacology, and the opportunity to collaborate closely with an array of thought-leaders in the drug development community.
During my brief time as an Assistant Professor at Oregon State University, I have improved my grant writing proficiency and my ability to manage both research and teaching responsibilities. At OSU, I have also had the opportunity to expand the scope of my research interests far beyond CYP24A1. Current projects in my laboratory are focused on broader subjects related to antisense drug development, immunotoxicology and systems approaches to biology that include RNA-seq methodologies, and both targeted and untargeted metabolomics approaches targeting orphan CYP gene function. I am particularly interested in studying the evolution of CYP genes, and the role that alternative gene splicing plays in modulating the function of both nuclear hormone receptors (NHRs) and CYPs. Because both genetic polymorphisms and epigenetic factors (e.g. age, diet & xenobiotic exposure) can alter pre-mRNA splicing in unpredictable ways, improved understanding of the transcriptome and metabolome will be crucial to achieving precision medicine in the post-genomic era. Information gained from my research will elaborate NR and CYP structure/function, facilitate rational drug development, and improve personalized-approaches to medicine by refining the predictive power of genetic screening and genome-wide association studies (GWAS).
研究兴趣
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METABOLITESno. 9 (2023): 985-985
International journal of tryptophan research : IJTR (2023): 11786469231182508
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#Papers: 26
#Citation: 524
H-Index: 11
G-Index: 22
Sociability: 5
Diversity: 0
Activity: 0
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