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The genetic landscape faced by a living cell is constantly changing. Developmental transitions, environmental shifts, and pathogenic invasions lend a dynamic character to both the genome and its activity pattern.We study a variety of natural mechanisms that are utilized by cells adapting to genetic change. These include mechanisms activated during normal development and systems for detecting and responding to foreign or unwanted genetic activity. At the root of these studies are questions of how a cell can distinguish "self" versus "nonself" and "wanted" versus "unwanted" gene expression.
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Current Biology (2024)
Ivan N Zheludev, Robert C Edgar, Maria Jose Lopez-Galiano,Marcos de la Peña,Artem Babaian,Ami S Bhatt,Andrew Z Fire
bioRxiv : the preprint server for biology (2024)
MOLECULAR BIOLOGY AND EVOLUTIONno. 12 (2023)
bioRxiv : the preprint server for biology (2023)
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