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Andrew Read's work has revealed the evolutionary forces that shape pathogen virulence, infectivity, vaccine escape and drug resistance in a number of significant human infections. His work on malaria has provided a substantial body of experimental evidence to show that within-host selective pressures drive the evolution of both virulence and drug resistance. Integrating mathematical models with his experimental evidence, he proposed the controversial hypothesis that some vaccines can prompt evolution of more virulent pathogen strains. Recently he confirmed this hypothesis by evolving rodent malaria parasites in mice immunised with a candidate human malaria vaccine and showing virulence increased as predicted. He also developed both the theory and the proof of principle for the production of evolution-proof insecticides and provided the critical experimental evidence that animals have genetic variation in tolerance, a host defence mechanism which complements the more conventionally studied resistance.
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论文共 274 篇作者统计合作学者相似作者
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Alejandro Ortigas-Vásquez,Utsav Pandey,Daniel Renner, Chris Bowen, Sue Baigent,John Dunn,Hans Cheng,Yongxiu Yao,Andrew F Read,Venugopal Nair, Dave A Kennedy,Moriah L Szpara
bioRxiv : the preprint server for biology (2023)
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Evolution, medicine, and public healthno. 1 (2023): 185-186
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Evolution, medicine, and public healthno. 1 (2023): 163-173
Robert J. Woods, Meghan Forstchen,Clare Kinnear, Jordan McKaig,Twisha Patel, Kevin Tracy,Carol Young,Andrew F. Read
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Kathryn R Hayden,Matthew Jones,Kyle R. Elkin,Michael J Shreve, William Irvin Clees,Shirley Clark,Michael Mashtare,Tamie Veith,Herschel Elliott,John Watson,Justin Silverman, Thomas Richard,
Journal of Environmental Qualityno. 5 (2022): 1066-1082
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