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T and B lymphocytes are key components of vertebrate immune systems. They form richly structured and highly interactive communities that provide protection against infection while maintaining tolerance to innocuous antigens. They also encode immunological memory, responding rapidly and potently to previously encountered antigens. Our research integrates theoretical and computational tools with more traditional experimental approaches to study multiple aspects of lymphocyte dynamics. Our aim is to develop a mechanistic understanding of the rules underlying lymphocyte development, homeostasis, and their trajectories in response to antigen challenge. Our philosophy is to confront and break models with data to search for robust and quantitative explanations of immunological phenomena. Our current interests relate to the population dynamics of circulating lymphocytes, with particular focus on the impact of age on their persistence and function; the ecology of tissue-resident memory T cells; the recovery of lymphocyte subsets following hematopoietic stem cell transplantation; and the responses of HIV-infected infants to antiretroviral therapy.
Research Interests
Papers共 147 篇Author StatisticsCo-AuthorSimilar Experts
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European Conference on Information Retrievalpp.303-317, (2024)
Annual International ACM SIGIR Conference on Research and Development in Information Retrievalpp.3029-3032, (2024)
SIGIR 2024 (2024): 924-934
ACM TRANSACTIONS ON INFORMATION SYSTEMSno. 3 (2024): 1-30
M. Elise Bullock,Thea Hogan,Cayman Williams,Sinead Morris,Maria Nowicka, Minahil Sharjeel,Christiaan van Dorp,Andrew J. Yates,Benedict Seddon
biorxiv(2024)
arxiv(2024)
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Ciara D. Gillespie,Andrew Yates, Mark Hughes,Karl Ewins, Gabriella McMahon,John Hynes,Mark C. Murphy,Marie Galligan,Sebastian Vencken,Ekele Alih, John Varden,Jennifer Donnelly,
European Radiologyno. 8 (2024): 1-10
Nature Communicationsno. 1 (2024): 1-20
Sanmoy Pathak,Thea Hogan,Sanket Rane, Yundi Huang, Charles Sinclair,Simon Barry,Larissa Carnevalli,Andrew Yates,Benedict Seddon
bioRxiv : the preprint server for biology (2024)
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Author Statistics
#Papers: 151
#Citation: 19798
H-Index: 43
G-Index: 140
Sociability: 7
Diversity: 0
Activity: 2
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