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Bio
Professor McCulloch directs the Cardiac Mechanics Research Group where his team uses experimental and computational models to investigate the relationships between the cellular and extracellular structure of cardiac muscle and the electrical and mechanical function of the heart during ventricular remodeling and cardiac arrhythmia. Genetically engineered animal models are used to investigate the role of mechanotransduction in ventricular development, hypertrophy and post-myocardial infarction remodeling. Tissue engineering of the cell microenvironment using microlithography and microfluidics are used to investigate the role of cell-matrix interactions in cardiac mechanical signaling. Computational modeling together with fluorescence optical mapping are used to investigate excitation-contraction coupling and the role of mechanoelectric feedback in action potential propagation. In-silico modeling of signal transduction pathways related to calcium cycling and hypertrophy is a new research area along with the development of new technologies for high-throughput cardiac phenotyping in model organisms.
Research Interests
Papers共 554 篇Author StatisticsCo-AuthorSimilar Experts
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Heart Rhythmno. 5 (2024): S216
Journal of cardiovascular electrophysiology (2024)
Biophysical Journalno. 3 (2024)
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGYno. 5 (2024): 916-928
bioRxiv : the preprint server for biology (2024)
Science Advancesno. 17 (2023)
Viviane Timmermann,Samuel T. Wall,Joakim Sundnes, T. Alexander Quinn,Andrew D. McCulloch,Andrew G. Edwards
arxiv(2023)
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Author Statistics
#Papers: 559
#Citation: 23996
H-Index: 79
G-Index: 141
Sociability: 8
Diversity: 3
Activity: 65
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