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My lab is interested in the mechanisms that control vascular damage and how to influence repair and regeneration of the vascular system using innovative therapies, including gene-, cell- and RNA-based approaches. Focusing on vascular smooth muscle and endothelial cells, we are defining the non-coding RNA pathways and networks that influence cell function in health and disease and developing interventions to influence beneficially repair and regeneration. We additionally have focus on gene therapy, both in the translational and basic sense. We have developed an innovative gene therapy approach to prevent pathological vascular remodelling associated with coronary artery bypass graft failure and are pursuing this at the clinical interface. We are also generating endothelial cells from human embryonic stem cells for regeneration in ischaemic conditions, and developing an understanding in mechanisms that control endothelial cell commitment and specification.
Research Interests
Papers共 417 篇Author StatisticsCo-AuthorSimilar Experts
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Qi Zhang, Nobuhiro Yaoita, Arata Tabuchi, Shaofei Liu,Shiau-Haln Chen, Qiuhua Li,Niklas Hegemann, Caihong Li,Julie Rodor, Sara Timm,Hebatullah Laban,Toren Finkel,
Circulation (2024)
EUROPEAN HEART JOURNALno. 9 (2024): 642-644
CARDIOVASCULAR RESEARCHno. 3 (2024): 223-236
Victoria J. M. Reid, Wesley K. X. McLoughlin, Kalyani Pandya, Holly Stott,Monika Iškauskienė,Algirdas Šačkus, Judit A. Marti,Dominic Kurian,Thomas M. Wishart,Christophe Lucatelli,Dan Peters,Gillian A. Gray,
EJNMMI Researchno. 1 (2024): 7-7
Hywel Dunn-Davies,Tatiana Dudnakova, Antonella Nogara,Julie Rodor,Anita C. Thomas, Elisa Parish,Philippe Gautier,Alison Meynert,Igor Ulitsky,Paolo Madeddu,Andrea Caporali,Andrew Baker,
VASCULAR PHARMACOLOGY (2024): 107277-107277
British journal of pharmacology (2024)
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