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个人简介
The main goal of my PhD project has been to define new roles of the cellular Prion Protein (PrPC). PrPC was discovered as the causative agent of Spongiform Encephalopathies however further studies related it with several neuronal functions such as synapse regulation, neuronal survivor or cooper homeostasis. Our project has been focused on a broad and non-reductionist vision of this pathology trying to understand the consequences of PrPC alterations in the CNS.
On one side, we developed the first iPSC model from a patient with a familiar Prionopathy related with a PrPC mutation that causes Gerstmann-Sträussler-Scheinker syndrome (A. Matamoros-Angles et al, 2018. Molecular Neurobiology). In this work, we reproduce a common comorbid pathology associated with this disease, the Tauopathy, postulating PrPC as a modulator of pathological Tau phosphorylation. Part of this project was carried out in Isidre Ferrer’s Lab (Idibell, Barcelona). Secondly, we described the neuroprotective role of PrPC in epilepsy performing kainate-based epileptogenic treatments in vitro and in vivo with different mice models (P. Carulla et al, 2015. Scientific Reports). Finally, we went further trying to define the role of PrPC in the synapse (A. Matamoros-Angles et al, in preparation). Here, we performed Ca2+ imaging of primary neuronal cultures, different electrophysiological recordings of awake mice and behavioral test with Prnp-knock-out mice to study de consequences of PrPC absence in neuronal firing and synaptic function.
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论文共 14 篇作者统计合作学者相似作者
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A. Matamoros-Angles, E. Karadjuzovic,B. Mohammadi,F. Song,S. Brenna,B. Siebels,H. Voß,C. Seuring,I. Ferrer, H. Schlüter,M. Kneussel,HC. Altmeppen,
biorxiv(2024)
Trillium extracellular vesiclesno. 1 (2023): 14-18
M. Shafiq,A. Matamoros-Angles, L. Amin,B. Mohammadi, E. Karadjuzovic, S. Da Vela, I. Egger, A. Zafar,C. Seuring,B. Siebels, H. Voss, H. Schlueter,
BRAIN PATHOLOGY (2023)
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Neural Regeneration Researchno. 9 (2023): 1869-1875
A. Matamoros-Angles,A. Hervera,J. Soriano,E. Martí, P. Carulla,F. Llorens,M. Nuvolone,A. Aguzzi, I. Ferrer,A. Gruart, J. M. Delgado-García,J. A. Del Río
A. Matamoros-Angles,A. Hervera,J. Soriano,E. Martí, P Carulla,F. Llorens,M Nuvolone,A. Aguzzi, I. Ferrer,A. Gruart,JM. Delgado-García, JA. Del Río
crossref(2021)
A. Matamoros-Angles,A. Hervera,J. Soriano,E. Martí, P Carulla,F. Llorens,M Nuvolone,A. Aguzzi, I. Ferrer,A. Gruart,JM. Delgado-García, JA. Del Río
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