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Bio
The focus of my research is on the systems biology of aging, taking an integrative view of a biological process that disturbs a broad range of cellular and physiological functions in a complex and global fashion. We explore concepts from engineering (complex systems, robustness, control theory) to decipher the mechanisms of aging at the intersection of experimental, computational, and theoretical biology. We have established an aging model for post-mitotic cells through “Energy Restriction in Quiescence” (ERiQ). This experimental platform resembles metabolic stress responses and transcriptional regulation seen in many aging tissues, which may underlie the development of age-related diseases involving deregulation of the Akt, mTOR, NF-kappaB and p53 signaling pathways.
Research Interests
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