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个人简介
Single-molecule methods have emerged as powerful tools in life science research. These techniques allow the detection and manipulation of individual biological molecules and investigate, with unprecedented resolution, their conformations and dynamics at the nanoscale level. In my research I apply single-molecule techniques to biological problems that are important for human diseases.
The goal of my current research is to elucidate the precise molecular mechanisms by which the chaperones UNC-45 and Hsp90 assist in the folding of the myosin head which is critical for sarcomere assembly during development and repair of stress-induced damage to sarcomeres in mature muscle. Developing an understanding of these mechanisms is a problem at the core of muscle development and function.
The goal of my current research is to elucidate the precise molecular mechanisms by which the chaperones UNC-45 and Hsp90 assist in the folding of the myosin head which is critical for sarcomere assembly during development and repair of stress-induced damage to sarcomeres in mature muscle. Developing an understanding of these mechanisms is a problem at the core of muscle development and function.
研究兴趣
论文共 138 篇作者统计合作学者相似作者
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microPublication biology (2024)
Journal of Biological Chemistryno. 3 (2024)
Journal of Biological Chemistryno. 3 (2023): 104018-S547
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Molecular Biology of the Cellno. 9 (2023)
Courtney J. Matheny,Hiroshi Qadota, Marion Kimelman,Aaron O. Bailey,Andres F. Oberhauser,Guy M. Benian
bioRxiv (Cold Spring Harbor Laboratory) (2022)
Hiroshi Qadota, Annie McPherson, Rachel Corbitt, Evan Kelton Dackowski,Yohei Matsunaga,Andres Oberhauser,Guy M. Benian
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