My research program focuses on advancing the science of knowledge synthesis. Basing decisions on expert opinion or the results from one study can be misleading. Experts often recommend interventions that are ineffective and sometimes recommend interventions that are harmful. In addition, spurious or biased results may arise from a single study. Systematic reviews (or knowledge synthesis) focus on the totality of evidence and are the base unit of knowledge translation products, such as patient decision aids, policy briefs, and clinical practice guidelines. They are the cornerstone of evidence-informed practice.