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Current research
In the Bach Group, we develop biological active small-molecule inhibitors of protein-protein interactions involved in oxidative stress and which play key roles in inflammation and brain diseases (e.g. neurodegeneration and brain cancer). We evaluate the ‘druggability’ of selected targets, and aim at developing new high-quality chemical probes useful for pharmacological studies and for identifying new therapeutic principles against diseases.
Fragment-based drug discovery (FBDD) is a core theme of our research. We screen our library of fragments (i.e. small substructures of druglike molecules) using very sensitive biophysical methods, such as SPR and NMR. Promising and validated hits are optimized into lead molecules by medicinal chemistry, biostructural studies and pharmacology.
In the Bach Group, we develop biological active small-molecule inhibitors of protein-protein interactions involved in oxidative stress and which play key roles in inflammation and brain diseases (e.g. neurodegeneration and brain cancer). We evaluate the ‘druggability’ of selected targets, and aim at developing new high-quality chemical probes useful for pharmacological studies and for identifying new therapeutic principles against diseases.
Fragment-based drug discovery (FBDD) is a core theme of our research. We screen our library of fragments (i.e. small substructures of druglike molecules) using very sensitive biophysical methods, such as SPR and NMR. Promising and validated hits are optimized into lead molecules by medicinal chemistry, biostructural studies and pharmacology.
Research Interests
Papers共 143 篇Author StatisticsCo-AuthorSimilar Experts
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Scientific datano. 1 (2024): 44-44
Nicole Fadahunsi,Jonas Petersen,Sophia Metz,Alexander Jakobsen,Cecilie Vad Mathiesen, Alberte Silke Buch-Rasmussen, Nigel Kurgan,Jeppe Kjærgaard Larsen,Rita C Andersen,Thomas Topilko, Charlotte Svendsen,Mia Apuschkin,
Science advancesno. 9 (2024): eadg2636-eadg2636
Jonas Petersen,Mette Q Ludwig, Vaida Juozaityte,Pablo Ranea-Robles, Charlotte Svendsen,Eunsang Hwang, Amalie W Kristensen,Nicole Fadahunsi,Jens Lund, Alberte W Breum,Cecilie V Mathiesen, Luisa Sachs,
Natureno. 8014 (2024): 1133-1141
Nane Griem-Krey,Anders B. Klein,Bettina H. Clausen,Mathias R. J. Namini,Pernille Nielsen, Mozammel Bhuiyan, Raghavendra Y. Nagaraja,T. Michael De Silva, Christopher G. Sobey,Heung-Chin Cheng,Cyrille Orset,Denis Vivien,
Journal of cerebral blood flow and metabolismno. 8 (2023): 1419-1434
Jonas Salling Quist,Anders Bue Klein, Kristine Faerch, Kristine Beaulieu, Mads Rosenkilde, Anne Sofie Gram, Anders Sjodin, Signe Torekov, Bente Stallknecht, Christoffer Clemmensen, Martin Baek Blond
Nature metabolismno. 4 (2023): 677-698
ACS chemical neuroscienceno. 17 (2023): 3212-3225
Henri Chédotal,Dilip Narayanan, Katrine Povlsen,Charlotte H Gotfredsen,Roberta Brambilla,Michael Gajhede,Anders Bach,Mads H Clausen
Drug discovery todayno. 6 (2023): 103575-103575
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Author Statistics
#Papers: 130
#Citation: 4168
H-Index: 32
G-Index: 60
Sociability: 7
Diversity: 4
Activity: 46
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