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Bio
Our mission: to discover the changes that occur in the brain in patients with major depression so that we can identify better therapies to treat depression.
The biological basis of depression: Major depressive disorder is one of the most common and costly of neuropsychiatric syndromes, with a lifetime prevalence of 7-12% in men and 20-25% in women, and a multi-billion dollar annual economic burden in the US. The most tragic consequence of untreated depression is suicide, attempted by as many as 8% of severely depressed patients. According to the Centers for Disease Control and Prevention, nearly half a million patients receive emergency care for suicide attempts each year in the United States and over 38,000 individuals die by intentional self-inflicted injuries - twice as many lives as are lost to homicide.
Stressful life events are a key environmental risk factor for depressive disorders. Our laboratory uses chronic stress to produce changes in the behavior of rats and mice that are analogous to the behavioral symptoms of human depression, such as anhedonia (the inability to derive pleasure from things that should be pleasurable). We can then analyze brain tissue taken from animals whose behavior was affected by stress and use electrophysiological, biochemical, and molecular assays to identify the underlying pathological changes.
Research Interests
Papers共 302 篇Author StatisticsCo-AuthorSimilar Experts
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Journal of neurophysiologyno. 1 (2024): 64-74
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacologyno. 2 (2024): 443-454
Molecular psychiatrypp.1-12, (2024)
crossref(2023)
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Aileen M Bailey, Allison Barrett,Lane Havens, Erica Leyder, Taylor Merchant,Hannah Starnes,Scott M Thompson
Behavioural brain research (2023): 114554-114554
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