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个人简介
Current Research Interests
My current research focuses on investigating the impact of the oral microbiota on the host's ability to withstand the presence of pathobionts and pathogens in the respiratory tract. Recently, we have demonstrated that the oral microbiota is associated with the severity of chronic obstructive pulmonary disease (COPD) (Dias et al. Respir Res 2022), and have found that specific changes in the oral microbiota are linked to responsiveness of patients with COPD to pulmonary rehabilitation (Dias et al. Respir Res 2023). Additionally, we are studying how inflammageing affects the evolution of gut microbiota using both in vitro and in vivo models such as mice (Barreto et al. Curr Biol 2020) and Drosophila.
Carreer Path
After completing my Microbiology and Genetics degree, I earned a PhD in Molecular Evolution at the University of Lisbon in 2008, where we used experimental phylogenies to test phylogenetic inference methods. As a Postdoctoral Researcher at the Instituto Gulbenkian Ciencia (IGC) in 2008, I studied microbial adaptation. Our work was key to show that epistasis plays a crucial role in the maintenance of antibiotic resistance (Sousa et al., Mol Biol Evol 2012). We also found that commensal bacteria are rapidly evolving in their natural environment, the mammalian gut (Barroso-Batista**, Sousa** et al., PLoS Genet 2014; Lourenço et al., PLoS Genet 2016; Sousa et al., Mol Biol Evol 2017; Frazão et al., PNAS 2019). In particular, (Barroso-Batista**, Sousa** et al. PLoS Genet 2014) is one of the first works showing how experimental evolution in vivo can unravel evolutionary change in the microbiota. In 2016, I became a principal investigator at the Institute of Biomedicine (University of Aveiro) and started my research group. Our research focuses on the interplay between the airway microbiota and chronic obstructive pulmonary disease (COPD) and the interplay between the gut microbiota and ageing.
In addition to research, I was an Assistant Professor at the University Lusophone of Humanities and Technology from 2004 to 2013 (Lisbon). Currently I am an Assistant Professor at the University of Aveiro since 2016.
研究兴趣
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European Business Review (2024)
Sonia D. Coelho,Tiago Maricoto,Luis Taborda-Barata, Isabella Annesi-Maesano,Tomohiko Isobe,Ana C. A. Sousa
ENVIRONMENTAL POLLUTION (2024): 123733-123733
INTERNATIONAL JOURNAL OF CONSUMER STUDIESno. 1 (2024)
SCIENCE OF THE TOTAL ENVIRONMENT (2024): 171699-171699
Topics in Clinical Nutritionno. 2 (2024): 93-103
INTERNATIONAL JOURNAL OF EVENT AND FESTIVAL MANAGEMENTno. 2 (2024): 170-190
International forum of allergy & rhinologyno. 1 (2024): 18-31
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 4 (2024): 2324
PLANTS PEOPLE PLANETno. 3 (2024): 587-603
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