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职业迁徙
个人简介
My research interests surrounds the study of the cellular and molecular immune mechanisms that regulate chronic infectious diseases such as leishmaniasis, paracoccidioidomycosis, and periodontal disease, with a major focus on understanding the involvement of regulatory T cells in these processes. During my PhD studies I have identified the critical role of regulatory T cells in immunosuppression during cutaneous leishmaniasis. Research in my laboratory has investigated the immunosuppressive mechanisms that modulate the development of chronic inflammatory infections in oral mucosa, showing that inhibitory signals mediated via molecules such as programmed death-1 (PD-1) play a critical role in modulating immune responses during chronic periodontitis. Over the last 5 years have also extensively investigated immunoregulatory mechanisms associated with cancer development in an attempt to identify new targets for cell-based therapeutic approaches. Our studies have shown that loss of inflammasome function and the recruitment of Treg CCR5+ ablated the development of a protector response against Squamous cell carcinoma (SCC) and negatively affected the anti-tumor immune response.
研究兴趣
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Thaís Helena Gasparoto, Thalita Marcato Dalboni,Nádia Ghinelli Amôr, Aneli Eiko Abe,Graziela Perri,Vanessa Soares Lara,Narciso Almeida Vieira,Carlos Teodoro Gasparoto,Ana Paula Campanelli
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