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Research in the Hamdoun lab focuses on cellular mechanisms of small molecule transport, including drugs, endogenous signal molecules, and environmental toxicants. The research has revealed novel roles of transporter systems in the environmental movements of pollutants and in embryonic development. The lab has pioneered the study of interactions of ubiquitous environmental toxicants with ABCB1 (aka P-glycoprotein) one of the major transporters in humans and wildlife. This has included discovery of novel classes of environmental toxicants, termed Transporter Interfering Chemicals (TICs), which interfere with transporter systems in humans and wildlife. These include legacy and emerging persistent organic pollutants, such as DDT and flame retardants, that are transferred to humans through contaminated seafood. The research has also revealed windows of vulnerability to xenobiotic exposure during early life stages, and uncovered unexpected roles for transporters in regulation of signals that govern differentiation. This work has implications for understanding the health impacts of in utero chemical exposures.
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crossref(2024)
Developmental dynamics : an official publication of the American Association of Anatomists (2024)
biorxiv(2024)
Journal of experimental zoology. Part B, Molecular and developmental evolutionno. 3 (2023): 313-329
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Matthew E Michel,Christopher C Wen,Sook Wah Yee,Kathleen M Giacomini,Amro Hamdoun,Sascha C T Nicklisch
Clinical pharmacology and therapeuticsno. 6 (2023): 1293-1303
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2023)
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Elsevier eBookspp.181-201, (2023)
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DEVELOPMENTAL BIOLOGY (2023): 68-82
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