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KEYWORDS
Lymphatic Vessels, Cutaneous Immunity, Melanoma, T cell Trafficking, Lymph Nodes
SUMMARY
The lymphatic vasculature is the critical interface between peripheral tissues and secondary lymphoid organs where adaptive immune responses are initiated. Though the immune response and the lymphatic vasculature are anatomically and functionally related, the contribution of these vessels to anti-tumor immunity remains underappreciated and unexplored. Our group tests the hypothesis that the lymphatic vasculature is an active regulator of cutaneous and tumor immunity both serving as the requisite route for immune priming and directly contributing to multiple mechanisms of immune resolution and tumor immune escape. We apply novel tools to track and quantify lymphatic biology in vivo, including three-dimensional and high-content imaging, in situ photoconversion, bulk and single-cell transcriptomics, and cell-specific proteomics strategies. By elucidating novel mechanisms of lymphatic vessel-mediated immune control, we are working towards the long-term goal of identifying novel targets and strategies to use the lymphatic vasculature to tune immune function to enhance cancer immunotherapy.
KEYWORDS
Lymphatic Vessels, Cutaneous Immunity, Melanoma, T cell Trafficking, Lymph Nodes
SUMMARY
The lymphatic vasculature is the critical interface between peripheral tissues and secondary lymphoid organs where adaptive immune responses are initiated. Though the immune response and the lymphatic vasculature are anatomically and functionally related, the contribution of these vessels to anti-tumor immunity remains underappreciated and unexplored. Our group tests the hypothesis that the lymphatic vasculature is an active regulator of cutaneous and tumor immunity both serving as the requisite route for immune priming and directly contributing to multiple mechanisms of immune resolution and tumor immune escape. We apply novel tools to track and quantify lymphatic biology in vivo, including three-dimensional and high-content imaging, in situ photoconversion, bulk and single-cell transcriptomics, and cell-specific proteomics strategies. By elucidating novel mechanisms of lymphatic vessel-mediated immune control, we are working towards the long-term goal of identifying novel targets and strategies to use the lymphatic vasculature to tune immune function to enhance cancer immunotherapy.
研究兴趣
论文共 99 篇作者统计合作学者相似作者
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Nature reviews. Cancerpp.1-19, (2024)
arxiv(2024)
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Julia Femel, Cameron Hill, Irineu Illa Bochaca,Jamie L. Booth,Tina G. Asnaashari,Maria M. Steele, Ata S. Moshiri, Hyungrok Do,Judy Zhong,Iman Osman,Sancy A. Leachman,Takahiro Tsujikawa,
FRONTIERS IN IMMUNOLOGY (2024): 1328602-1328602
Maria P Alcolea,Direna Alonso-Curbelo,Chiara Ambrogio,Susan Bullman,Ana Luísa Correia,Aurélie Ernst, Christopher J Halbrook,Gemma L Kelly,Amanda W Lund,Daniela F Quail,Marcus Ruscetti,Efrat Shema,
Cancer discoveryno. 4 (2024): 674-682
Marina T. Broz,Emily Y. Ko, Kristin Ishaya,Jinfen Xiao,Marco De Simone,Xen Ping Hoi,Roberta Piras, Basia Gala, Fernando H. G. Tessaro,Anja Karlstaedt,Sandra Orsulic,Amanda W. Lund,
Despoina Kalfakakou,Emily A. Kawaler, Dylan Tamayo,Lidong Wang, Rosmel Hernandez,Amanda Ackermann,Xiaohong Jing,Cristina Hajdu,Cynthia Loomis, Adrianna Heguy,Amanda W. Lund,Theodore H. Welling,
CANCER RESEARCHno. 2 (2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Ha -Ram Park,Anahita Shiva, Portia Cummings,Seoyeon Kim,Sungsoo Kim,Eunhyeong Lee,Alessandra Leong,Subrata Chowdhury,Carrie Shawber,Richard Carvajal,Gavin Thurston,Joon-Yong An,
Cancer researchno. 12 (2023): 1968-1983
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