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In developed countries, more than 15% of women develop pregnancy complications which are associated with placental insufficiency and fetal and maternal morbidity and mortality. Such complications include fetal growth restriction, premature birth, gestational diabetes and preeclampsia. To better understand the aetiology of these pregnancy complications and developmental processes in a wider context, my laboratory has been investigating the environmental and genetic control of placental morphogenesis and function and its relevance for fetal development, maternal health and the long-term programming of disease. Our work combines novel genetic tools and established environmental models, with in vivo functional assays and cellular, histological and molecular techniques in vitro. We also use donated human biomaterial from women. The research aims of the lab are:
1) To better understand the molecular mechanisms governing placental trophoblast differentiation and function.
2) To examine how the placenta may influence the metabolic and cardiovascular systems of the mother and thus, her capacity to partition resources to the developing fetus.
3) To determine how the placenta senses and responds to the maternal environment and thereby regulates fetal growth and development.
4) To identify whether changes in maternal-fetal resource allocation due to altered placental function has consequences for the developmental and health programme of the offspring later in life.
1) To better understand the molecular mechanisms governing placental trophoblast differentiation and function.
2) To examine how the placenta may influence the metabolic and cardiovascular systems of the mother and thus, her capacity to partition resources to the developing fetus.
3) To determine how the placenta senses and responds to the maternal environment and thereby regulates fetal growth and development.
4) To identify whether changes in maternal-fetal resource allocation due to altered placental function has consequences for the developmental and health programme of the offspring later in life.
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论文共 166 篇作者统计合作学者相似作者
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Placenta (2024): 49-59
CELLULAR AND MOLECULAR LIFE SCIENCESno. 1 (2024): 151-151
Zoé Oulerich,Amanda N Sferruzzi-Perri
American journal of physiology. Renal physiologyno. 1 (2024): F21-F36
Trends in endocrinology and metabolism: TEMno. 7 (2024): 638-647
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGYno. 5 (2024): 623-631
Methods in molecular biology (Clifton, N.J.) (2024): 1-13
Developmental Origins of Health and Diseasepp.166-176, (2023)
Alejandro A. Candia,Samantha C. Lean, Cindy X. W. Zhang,Daniel R McKeating, Anna Cochrane,Edina Gulacsi,Emilio A. Herrera,Bernardo J. Krause,Amanda N. Sferruzzi-Perri
Biochimica et biophysica acta. Molecular basis of diseaseno. 7 (2023): 166802-166802
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