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Bio
Laboratory of Cancer Genetics & Genomics
The main theme of the Monteiro lab is the integration of epidemiological, genomic, and proteomics datasets to explore the role of genetic variation on cancer predisposition, development, and treatment. We apply a systems biology approach to three interconnected problems in cancer.
First, we aim to understand how rare genetic (somatic or germline) variation impacts on signal transduction networks and its role in inherited cancer syndromes. We focus on the role of BRCA1 in cancer and integrate statistical, structural, and functional data to aid in clinical annotation of hundreds of variants found in the population. Our group pioneered the use of functional assays to analyze mutations in the BRCA1 BRCT domain to assess their pathogenicity. We have also developed interactive visualization tools to annotate functional data on BRCA variants (https://research.nhgri.nih.gov/bic/circos/) and participated in the development of BRCA Exchange (https://brcaexchange.org/).
Second, we seek to understand how BRCT domains convey signals during the cellular response to DNA Damage. We combine detailed large scale yeast two-hybrid screening and tandem-affinity purification coupled to mass spectrometry to generate an annotated protein-protein interaction network mediated by all BRCT domains in the human proteome. Using this network we identified AZD1775 as synergistic to platinum in lung cancer cells and currently have an ongoing clinical trial with stage IV lung cancer patients.
Finally, we are interested in the mechanism underlying cancer risk conferred by common genetic variants. We have played an active role in the NIH/NCI GAME-ON (Genetic Associations and Mechanisms in Oncology; http://epi.grants.cancer.gov/gameon/) consortium as part of the cross-GAME-ON Functional Working group. We have developed a conceptual framework as well as a bioinformatics and functional assay platform to systematically interrogate cancer predisposition loci revealed by GWAS of unprecedented sample sizes. This analytical framework includes chromosome conformation capture techniques, enhancer scanning techniques, ChIP-Seq, and liquid chromatography coupled to mass spectrometry, and organoids to functionally dissect cancer risk loci for breast and ovarian cancers and glioma.
Twitter: @AccidentalGenet
Google Scholar: http://scholar.google.com/citations?user=8D5gFOYAAAAJ&hl=en
Publons: https://publons.com/author/1303743/alvaro-na-monteiro#profile
NCBI My Bibliography:
https://www.ncbi.nlm.nih.gov/myncbi/1bIN9gxOqLdkEN/bibliography/public/
Research Interests
Papers共 301 篇Author StatisticsCo-AuthorSimilar Experts
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Cancer Researchno. 6_Supplement (2024): 6615-6615
Cancer Researchno. 6_Supplement (2024): 5608-5608
Thales C. Nepomuceno,Tzeh Keong Foo,Marcy E. Richardson,John Michael O. Ranola, Jamie Weyandt, Matthew J. Varga, Amaya Alarcon, Diana Gutierrez,Anna von Wachenfeldt, Daniel Eriksson,Raymond Kim,Susan Armel,
Huaizhi (Gilbert) Huang,Chunling Hu,Jie Na, Mohamed Abozaid,Amik Munankarmy, Tara Rao, Carolyn A. Dunn Lumby,Paulo Cilas Morais Lyra, Ronan E. Couch, Benjamin R. Persons,Eric C. Polley,Rachid Karam,
CANCER RESEARCHno. 3 (2024)
Marcy E. Richardson, Megan Holdren, Terra Brannan,Miguel de la Hoya,Amanda B. Spurdle,Sean V. Tavtigian, Colin C. Young, Lauren Zec, Susan Hiraki,Michael J. Anderson,Logan C. Walker,Shannon McNulty,
medrxiv(2024)
Dhanya Ramachandran,Jonathan P. Tyrer,Stefan Kommoss,Anna DeFazio,Marjorie J. Riggan,David Bowtell,Penelope M. Webb, Peter A. Fasching, Diether Lambrechts,María J. García,Cristina Rodríguez-Antona,Marc T. Goodman,
npj Genomic Medicineno. 1 (2024): 1-12
Thales C Nepomuceno,Paulo Lyra, Jianbin Zhu, Fanchao Yi, Rachael H Martin,Daniel Lupu, Luke Peterson,Lauren C Peres,Anna Berry,Edwin S Iversen,Fergus J Couch,Qianxing Mo,
JCO clinical cancer informaticsno. 8 (2024): e2300251-e2300251
Marcy E Richardson, Megan Holdren, Terra Brannan, Miguel de la Hoya,Amanda B Spurdle,Sean V Tavtigian,Colin C Young, Lauren Zec,Susan Hiraki,Michael J Anderson,Logan C Walker,Shannon McNulty,
medRxiv : the preprint server for health sciences (2024)
Chunling Hu,Huaizhi Huang,Jie Na, Carolyn Lumby, Mohamed Abozaid, Megan A Holdren, Tara J Rao,Rachid Karam,Tina Pesaran, Jamie D Weyandt, Christen M Csuy, Christina A Seelaus,
Michael T. Parsons, Miguel de la Hoya,Marcy E. Richardson, Emma Tudini,Michael Anderson, Windy Berkofsky-Fessler,Sandrine M. Caputo, Raymond C. Chan,Melissa C. Cline,Bing-Jian Feng, Cristina Fortuno,Encarna Gomez-Garcia,
medrxiv(2024)
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