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个人简介
Professor of Developmental Genetics at the Faculty of Sciences, University of Chile (2005-present), where he obtained his Biochemist degree (1998) and later his PhD in Molecular, cellular biology and Neurosciences (2002). I was a postdoctoral fellow (2002-2005 and 2005-2006). I received fellowships from CONCYT (1998), the Andes Foundation (1999-2002), EMBO (2002-2005), Woods Hole MBL (1999), and awards from the Developmental biologist organization (2000) for the Best Undergraduate and Magister thesis. Foundation for the Chilean Cellular Biology (1997), Hermann Niemeyer medal for Best PhD student. Sociedad de Bioquímica y Biología Molecular de Chile (1998), EMBL Advanced Training Centre Corp Partnership Program Fellowship (2017). He has taken part of: the Scientist of Frontier group of the Chilean Academy of Sciences (207-2010) Academic Steering Committees at U. Chile (Ph.D. in Molecular, cellular biology and Neurosciences, 2010-13 and Master in Biological Sciences, 2014-2021); Scientific Society Boards (Chilean Society of Cellular Biology 2019-2021. He was director the associative research Ring for Developmental Adaptations to Nutritional Stress (2015-2018). My Laboratory of Developmental Genetics uses a trans-disciplinary approach, taking advantage of the genetic tools and amenability of the fly model, to address the cellular and genetic mechanisms of growth control, translation and stress responses.
My basic science research investigates the mechanisms that regulate the size of organisms as the result of coordinated proliferation, cell death and cell growth. We have focus our research to investigate how the mechanisms that integrate and transduce the environmental cues that control cellular and animal growth are adjusted by the growth potential of the cells, tuning the biosynthetic enhancement to support sustainable cell and animal growth. Specifically, we use power of Drosophila as a model system to answer questions regarding to cell growth and survival response to nutritional and genetic perturbations in imaginal cells and hematopoietic tissue. Our last research has focused in the role of tRNA modifications and protein homeostasis in animal context. We demonstrated a novel relationship between the translation machinery and TOR kinase, where translation efficiency, limited by the availability of modified tRNA, defines TOR activity levels that ultimately control growth potential in eukaryotic cells.
Our second research line is aimed to investigate how environmental challenges tune developmental programs and conditions adulthood at different levels, from the molecular aspects of tissue specific epigenetics and gene expression to behavior. Specially relevant are the environmental effects on brain development, metabolism and physiology.
研究兴趣
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crossref(2024)
International journal of molecular sciencesno. 8 (2023): 7485-7485
OPEN BIOLOGYno. 5 (2023): 230049
Nature Cell Biologyno. 5 (2021): 577-577
Research Square (Research Square) (2021)
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