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Chronic kidney disease (CKD) is a significant and growing public health problem. It is currently estimated that 13% of the adult population has CKD and it confers a 5-fold increased risk of premature cardiovascular disease and death. Those who survive long enough eventually require renal replacement therapy with dialysis or a kidney transplant. Many of the risk factors for CKD begin in childhood. a patient develops CKD, the pathological changes that worsen dysfunction are similar in all kidney diseases, and are characterized by a process of ongoing scarring or fibrosis. Despite tremendous progress in our understanding of the causes and consequences of CKD, effective therapies are unknown. Using experimental models of CKD, our studies are designed to investigate how specific cells and molecules mediate kidney fibrosis, with the ultimate goal of translating our findings into new human therapies.
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Papers共 158 篇Author StatisticsCo-AuthorSimilar Experts
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Pediatric nephrology (Berlin, Germany)no. 11 (2023): 3757-3768
Kidney Internationalno. 5 (2021): 1073-1076
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American journal of kidney diseases : the official journal of the National Kidney Foundationno. 4 (2020): 533-545
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