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个人简介
Our lab studies regulated protein post-translational modifications. We’re particularly interested in the ubiquitin-proteasome system as it relates to normal physiology, cancer, infectious diseases, cardiovascular disease, and other disorders. Research is focused in four major areas: 1) structure-function relationships of ubiquitin-conjugating enzymes (E2s), ubiquitin protein ligases (E3s), and deubiquitinating enzymes (DUBs); 2) the ubiquitin system at the endoplasmic reticulum (ER) including: ER-associated degradation (ERAD), cellular stress responses, regulation of lipid biosynthesis, and regulation of the innate immune response; 3) the ubiquitin system in mitochondrial regulatory processes and removal of damaged proteins; and 4) the role of ubiquitin system in removing bacterial toxins from cells. Our research program utilizes a wide variety of approaches and employs systems that include cancer cell lines, yeast, mice, and human tissue samples.
研究兴趣
论文共 159 篇作者统计合作学者相似作者
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Mei Yang,Jennifer Mariano, Rebecca Su,Christopher E. Smith,Sudipto Das, Catherine Gill,Thorkell Andresson,Jadranka Loncarek,Yien Che Tsai,Allan M. Weissman
JOURNAL OF BIOLOGICAL CHEMISTRYno. 12 (2023): 105346-105346
Meredith B. Metzger,Jessica L. Scales, Garis A. Grant, Abigail E. Molnar,Jadranka Loncarek,Allan M. Weissman
Journal of Biological Chemistry (2023)
crossref(2023)
Christopher E. Smith,Yien Che Tsai,Yu-He Liang,Domarin Khago,Jennifer Mariano,Jess Li,Sergey G. Tarasov, Emma Gergel, Borong Tsai, Matthew Villaneuva,Michelle E. Clapp,Valentin Magidson,
PLoS biologyno. 12 (2021): e3001474-e3001474
crossref(2021)
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作者统计
#Papers: 158
#Citation: 23748
H-Index: 73
G-Index: 140
Sociability: 6
Diversity: 3
Activity: 15
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