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Dr. Klein is a Professor of Oncology, Pathology and Epidemiology and a trained genetic epidemiologist/statistical geneticist. She has studied the genetic epidemiology of pancreatic cancer for over 17 years. Her research has focused on the discovery of pancreatic cancer susceptibility genes, using linkage, sequencing and association approaches as well as quantification of pancreatic cancer risk due to familial and genetic factors. As part of this work, she has identified rare variants in PALB2 and ATM are associated with familial pancreatic cancer, as well as lead the Pancreatic Cancer Case Control Consortium Genome-Wide association studies of pancreatic cancer (NCI RO1/CIDR supported).
Dr. Klein is Director of the National Familial Pancreas Tumor Registry, the largest single-site registry of familial pancreatic cancer in the world. Currently, over 6,500 families have enrolled in this registry including over 1,700 with familial pancreatic cancer (i.e., defined as a kindred with at least a pair of first-degree relatives with pancreatic cancer). In addition, she is co-leader of the Familial Pancreatic Cancer Genome Sequencing Project conducted within the PACGENE consortium where we have recently completed whole genome sequencing analysis of 638 patients with familial pancreatic cancer. She is also the PI of a NCI/CIDR supported multi-center GWAS for pancreatic cancer and PI of the Johns Hopkins SPORE in Gastrointestinal cancer. She is a founding member of the Pancreatic Cancer Case-Control Consortium and member of the SU2C Pancreatic Cancer Interception Dream Team.
Dr. Klein is Director of the National Familial Pancreas Tumor Registry, the largest single-site registry of familial pancreatic cancer in the world. Currently, over 6,500 families have enrolled in this registry including over 1,700 with familial pancreatic cancer (i.e., defined as a kindred with at least a pair of first-degree relatives with pancreatic cancer). In addition, she is co-leader of the Familial Pancreatic Cancer Genome Sequencing Project conducted within the PACGENE consortium where we have recently completed whole genome sequencing analysis of 638 patients with familial pancreatic cancer. She is also the PI of a NCI/CIDR supported multi-center GWAS for pancreatic cancer and PI of the Johns Hopkins SPORE in Gastrointestinal cancer. She is a founding member of the Pancreatic Cancer Case-Control Consortium and member of the SU2C Pancreatic Cancer Interception Dream Team.
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论文共 38 篇作者统计合作学者相似作者
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Familial Cancerpp.1-10, (2024)
Adam H. Buchanan, Anne Marie Lennon, Seema P. Rego, Omair A. Choudhry, Paul Z. Elias, Jennifer R. Sadler,Joshua D. Cohen, Christopher B. Douville, Ashley M. Honushefsky,Alison Klein, Zachary M. Salvati,Kathleen Sheridan,
JOURNAL OF CLINICAL ONCOLOGYno. 16 (2023): 3037-3037
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Jihye Kim,Chen Yuan,Laufey T Amundadottir,Brian M Wolpin, Pancreatic Cancer Cohort Consortium (PanScan),Alison P Klein, Pancreatic Cancer Case–Control Consortium (PanC),Harvey A Risch,Peter Kraft
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncologyno. 9 (2023): 1242-1248
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncologyno. 9 (2023): 1265-1269
Chirayu Mohindroo,Seyda Baydogan,Parul Agarwal,Dan Laheru, Robin Wright,Laura Prakash,Maureen E. Mork,Alison Klein, Jess Maxwell,Matthew H. G. Katz,Arvind Dasari,Michael Paul Kim,
JOURNAL OF CLINICAL ONCOLOGYno. 16 (2023): 4135-4135
Nicolette J. Rodriguez, C. S. Furniss,Matthew B. Yurgelun,Chinedu Ukaegbu,Pamela E. Constantinou, Ileana Fortes, Alyson Caruso,Alison N. Schwartz,Jill E. Stopfer,Meghan Underhill-Blazey,Barbara Kenner,Scott H. Nelson,
GASTROENTEROLOGYno. 6 (2023): S45-S46
crossref(2023)
Expert review of gastroenterology & hepatologyno. 6 (2023): 555-574
Diabetesno. 4 (2023): 433-448
Anne Marie Lennon,Adam H. Buchanan, Seema P. Rego, Omair A. Choudhry, Paul Z. Elias, Jennifer R. Sadler,Joshua D. Cohen, Christopher B. Douville, Ashley M. Honushefsky,Alison Klein, Zachary M. Salvati, Kathleen Sheridan,
JOURNAL OF CLINICAL ONCOLOGYno. 16 (2023)
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