My research focuses on the following areas:
discovering novel genomic alterations and their role in germline predisposition to cancers
developing informatics framework for interpreting germline variations and assertion of pathogenicity
interrogating germline and somatic variations for targeted therapies
I am part of a multidisciplinary team investigating diverse heritable cancers. My current focus is on bladder, breast, prostate, and hematologic cancers. I work with several international consortia focusing on the genetics of cancer, including the Breast Cancer Association Consortium, the Consortium of Investigators of Modifiers of BRCA1/2, the International Lymphoma Epidemiology Consortium, and the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome consortium.
My research is funded by the National Institutes of Health, the Prostate Cancer Foundation, the V Foundation for Cancer Research, Cycle for Survival, and other groups.