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个人简介
A main focus of my research is the study of obesity, body fat distribution, intramuscular fat and their role in insulin resistance with emphasis on the effects of weight loss and exercise training on muscle and glucose metabolism in sedentary, overweight individuals. The basic research includes the study of mechanisms by which diet and exercise interventions (aerobic and resistive training) affect skeletal muscle and adipose tissue metabolism, insulin signaling and gene expression in muscle, and in vivo insulin action in sedentary older individuals.
In addition, my research involves the study of residual hemiparesis following stroke which leads to physical deconditioning and possibly muscle atrophy and abnormal metabolism due to disuse or aberrant neural innervation. We have described skeletal muscle atrophy and greater fat deposition within the muscle of the hemiparetic limb in chronic hemiparetic stroke patients which may contribute to functional disability and increased cardiovascular disease risk in chronic hemiparetic stroke patients. We are currently examining the muscle molecular phenotype and its relationship to gait deficit severity and interventions designed to prevent muscle atrophy and reduce insulin resistance which are needed to minimize the loss of functional independence and cardiovascular disease risk in older chronically disabled stroke patients.
In addition, my research involves the study of residual hemiparesis following stroke which leads to physical deconditioning and possibly muscle atrophy and abnormal metabolism due to disuse or aberrant neural innervation. We have described skeletal muscle atrophy and greater fat deposition within the muscle of the hemiparetic limb in chronic hemiparetic stroke patients which may contribute to functional disability and increased cardiovascular disease risk in chronic hemiparetic stroke patients. We are currently examining the muscle molecular phenotype and its relationship to gait deficit severity and interventions designed to prevent muscle atrophy and reduce insulin resistance which are needed to minimize the loss of functional independence and cardiovascular disease risk in older chronically disabled stroke patients.
研究兴趣
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Osteoarthritis and Cartilage Openno. 1 (2024): 100426-100426
Obesity (Silver Spring, Md.)no. 4 (2024): 667-677
ARTHRITIS CARE & RESEARCHno. 5 (2024): 673-681
The journals of gerontology. Series A, Biological sciences and medical sciencesno. 5 (2024)
Contemporary Clinical Trials (2024): 107412-107412
Krisann K Oursler,Brandon C Briggs,Alicia J Lozano, Nadine M Harris, Amitabh Parashar,Alice S Ryan,Vincent C Marconi, FIT VET Project Team
AIDS (London, England)no. 6 (2024): 825-833
American journal of physiology. Renal physiologyno. 3 (2024): F420-F437
INTERNATIONAL JOURNAL OF EPIDEMIOLOGYno. 1 (2024)
Cellsno. 19 (2023): 2366-2366
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