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Bio
Dr. Schaefer's research focuses on identifying quantitative trait loci, genes and alleles that regulate emerging viral pathogenesis and immunity using outbred mouse and human models, and the role of these loci in pathogenesis. A major goal is to identify and study common genes and polymorphisms that regulate emerging virus disease severity across species. One important hypothesis is that phylogenetically clustered, high-risk emerging sarbecoviruses and filoviruses are regulated by common susceptibility loci, across mammalian species, including humans. In parallel, I am interested in developing outbred population-based model systems of human disease that can be used not only to model coronavirus evolution, pathogenic potential, and virulence in real-time, but also to develop and test antiviral therapeutics (direct-acting antiviral and monoclonal antibodies) and vaccine performance against coronaviruses with pandemic potential.
Research Interests
Papers共 124 篇Author StatisticsCo-AuthorSimilar Experts
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Jacob A Dillard,Sharon A Taft-Benz,Audrey C Knight,Elizabeth J Anderson, Katia D Pressey,Breantié Parotti, Sabian A Martinez,Jennifer L Diaz,Sanjay Sarkar,Emily A Madden,Gabriela De la Cruz,Lily E Adams,
Nature communicationsno. 1 (2024): 3738-3738
Jessica B. Graham,Jessica L. Swarts,Sarah R. Leist,Alexandra Schafer,Timothy A. Bell,Pablo Hock, Joe Farrington,Ginger D. Shaw,Martin T. Ferris, Fernando Pardo -Manuel De,Ralph S. Baric,Jennifer M. Lund
ISCIENCEno. 3 (2024): 109103-109103
Virus research (2024): 199357-199357
Marnix Van Loock,Ellen Van Damme,Pravien Abeywickrema,Yanting Yin, Jiexiong Xie,Sofie Jacobs, Mandeep Mann,Robyn Miller, Madison Piassek,Jordi Doijen, Simone Marsili, Murali Subramanian,
crossref(2024)
Brian Montoya,Carolina R. Melo-Silva,Lingjuan Tang,Samita Kafle, Peter Lidskiy,Csaba Bajusz,Máté Vadovics,Hiromi Muramatsu,Edit Abraham,Zoltan Lipinszki, Debotri Chatterjee,Gabrielle Scher,
Molecular Therapyno. 6 (2024): 1790-1804
Cara W Chao,Kaitlin R Sprouse,Marcos C Miranda,Nicholas J Catanzaro, Miranda L Hubbard,Amin Addetia,Cameron Stewart,Jack T Brown,Annie Dosey, Adian Valdez,Rashmi Ravichandran, Grace G Hendricks,
bioRxiv : the preprint server for biology (2024)
Science Translational Medicineno. 748 (2024): eadj4504-eadj4504
Immunityno. 3 (2023): 669-686.e7
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