基本信息
浏览量:45
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
Eukaryotic cells that grow by polarised extension perform specialised, essential functions in vertebrates, plants and fungi. This disparate group of cells, which includes neurons, pollen tubes, root hairs and fungal hyphae, all share a similar function – they extend through their environment in order to make contact with their own specific target. To be successful, they must be able to interpret local signals that tell them which direction to grow (navigate) and they must be able to change their direction of growth if necessary (steer). The environmental signals that help neurons, pollen tubes and fungi to navigate differ greatly but they may share similar steering mechanisms because the cell components that regulate polarised growth are highly conserved. We are using the dimorphic fungus, Candida albicans, as a model organism in which to study how polarised cells navigate and steer. C. albicans displays tropic, or pre-programmed, growth behaviour under certain conditions and we are using these responses to study the molecular links between environmental signalling and the machinery that drives tip re-orientation. We have shown that loss of normal regulation in the hyphal tip correlates with the inability of the fungus to form normal lesions in internal organs during systemic infection. We want to understand which signals within the human body influence how the hyphal tip behaves during disease progression.
研究兴趣
论文共 49 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
NATURE REVIEWS MICROBIOLOGYpp.1-18, (2024)
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERSno. SUPPL 1 (2023): S199-S199
引用0浏览0引用
0
0
引用0浏览0引用
0
0
Journal of cell scienceno. 24 (2021)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn